Olanzapine - oral

Patient Medicine Information
Why do I need this medicine?
Olanzapine is used to treat schizophrenia (an illness that causes changes in perception, thoughts and behaviour). It helps to relieve symptoms common in schizophrenia, such as distorted thinking and emotional instability.

It is also used to treat a dysfunctional mood condition called bipolar disorder.
How do I take this medicine?
Take Olanzapine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine may be taken with or without food. Try to take it at the same time each day.

Olanzapine is available as a coated tablet, an orodispersible (orally disintegrating) tablet or as wafers.

If you have been given the coated tablet, swallow it whole with a glass of water.

If you have been given the orodispersible tablet, remove it from the foil only just before you take it. Place it directly in your mouth. It will dissolve quickly. Swallow it once it has dissolved in your mouth. You can also dissolve it in a glass of water, juice (orange or apple), milk or coffee just before you want to take it. Drink it immediately once the tablet has dissolved completely. The orodispersible tablet is easily broken. Handle it gently. Do not touch the tablet with wet hands.

If you have been given the wafer, remove it from the foil only just before you take it. Place it directly on the tongue. Allow it to dissolve and swallow it with your saliva. The wafer is easily broken. Handle it gently. Do not touch the wafer with wet hands.

Olanzapine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Olanzapine is not suitable for patients with dementia-related psychosis.

Alert your doctor if you have glaucoma (increased pressure in the eye) as this medicine may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have:

- an enlarged prostate or difficulty urinating
- epilepsy (fits) or a history of fits
- Parkinson's disease
- heart, liver or kidney disease
- bowel blockage or bowel paralysis (paralytic ileus) which causes severe constipation
- myasthenia gravis (a condition that causes muscle weakness)
- diabetes or have a history of diabetes
- high levels of cholesterol in the blood
- blood disorders
- thyroid disease
- risk factors for blood clot
- suicidal thoughts

Let your doctor know if you are pregnant or breastfeeding.

Olanzapine may affect the way your body adjusts to temperature changes in the environment. Avoid exposure to very cold or very hot environments.

The orodispersible tablet contains phenylalanine and may not be suitable for you if you suffer from phenylketonuria.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. He may need to do routine blood tests such as fasting blood glucose and lipid profile, before and periodically during your treatment with Olanzapine.
What side effects could I experience?
Olanzapine may cause dizziness and may also make you suddenly fall asleep during your daily activities. If affected, do not drive or take part in any activity in which you need to be alert. Dizziness may be worse when you get up from a sitting or lying down position, especially if you are taking Olanzapine for the first time or if your dose is still being adjusted. This is normal and should disappear gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying down position.

Some common side effects with Olanzapine include increased appetite, weight gain, dry mouth, constipation, indigestion, stomach discomfort, difficulty sleeping, tiredness, weakness and water retention.

Other side effects may need immediate medical help. Alert your doctor immediately if you experience any of the following:

- fast or irregular heartbeat
- feeling of restlessness or involuntary, repetitive body movement
- muscle stiffness, high fever, excessive sweating, altered mental status
- yellowing of the eyes or skin

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:

- medicine for anxiety e.g. diazepam, alprazolam
- medicines for cold and allergy e.g. antihistamines
- medicines for depression or mood disorders e.g. fluvoxamine, imipramine, lithium
- medicines for epilepsy (fits) e.g. carbamazepine, valproic acid
- medicine for Parkinson's disease e.g. levodopa
- certain antibiotics e.g. ciprofloxacin, rifampicin
- medicines for irregular heartbeat e.g. quinidine, procainamide

This list does not include all medicines that may interact with Olanzapine.

If you are taking activated carbon or activated charcoal pills, do not take them at the same time that you take Olanzapine. If you must take carbon or charcoal pills, take them at least 2 hours before or after Olanzapine.

Always notify your doctor or pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol. Alcohol will worsen the dizziness and drowsiness caused by Olanzapine.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on olanzapine - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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