Olaparib - oral

Patient Medicine Information
Why do I need this medicine?
Olaparib is used to treat advanced ovarian cancer (cancer that has spread outside the ovary) or recurrent ovarian cancer (cancer that have come back after previous treatment).
How do I take this medicine?
Take Olaparib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

This medicine is available as a tablet or a capsule. Swallow it whole with a glass of water. Do not open, break or chew the capsules. Do not cut, crush, or chew the tablets.

Olaparib must be taken regularly for it to be effective. Continue taking this medicine even when you feel well. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is more than 12 hours since you missed the dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Olaparib if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Olaparib may cause harm to your unborn child and may cause loss of pregnancy (miscarriage). It is important that you do not get pregnant while taking this medicine and for at least 6 months after stopping the treatment. You must use proven birth control methods while taking Olaparib. You may wish to discuss additional non-hormonal birth control methods with your doctor or pharmacist.

Do not breastfeed while you are being treated with this medicine and for at least 1 month after stopping the treatment.

Do not take Olaparib with any other anticancer medicine.
What should I take note of while taking this medicine?
Inform your doctor if you have liver or kidney disease.

Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • You may need to have routine blood tests (e.g. complete blood count, liver and kidney function tests) while you are being treated with Olaparib. Your doctor will advise you about how often you will need to have these tests.
  • Pregnancy test may be done prior to initiation, during and one month after medication.
What side effects could I experience?
Olaparib may cause dizziness, weakness or extreme tiredness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: diarrhoea, nausea, vomiting, loss of appetite, altered taste, headache, rashes, abdominal pain, muscle or joint pain, mouth sores, and heartburn (food or acid from your stomach backs up into your mouth, leaving a sour or bitter taste).

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • swelling of the face, lips, mouth, tongue, or throat
  • frequent and persistent sore throat with cough and fever
  • unusual bleeding or bruising
  • shortness of breath, cough
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Olaparib with any other anticancer medicine.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for fungal infection e.g. itraconazole, fluconazole
  • certain antibiotics e.g. clarithromycin, erythromycin, ciprofloxacin
  • medicines for epilepsy (fits or seizures) e.g. phenytoin, carbamazepine
  • medicines for high blood pressure or heart disease e.g. diltiazem, verapamil
  • medicine to treat TB (lung infection known as tuberculosis) e.g. rifampicin
  • medicines for HIV infection e.g. ritonavir, efavirenz, indinavir, saquinavir, nelfinavir
  • birth control pills e.g. drospirenone
  • herbal medicines e.g. St John’s Wort
This list does not include all medicines that may interact with Olaparib.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Avoid excessive consumption of grapefruit and Seville oranges (bitter oranges).
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from moisture.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.
This information is independently developed by MIMS based on olaparib - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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