Tab Adult Prevention of post-op nausea & vomiting (PONV) 16 mg given 1 hr prior anaesth.
Inj Adult
Chemotherapy & radiotherapy induced nausea & vomiting (CINV & RINV) 8 mg IV or IM immediately before treatment. Doses of ≤8 mg do not need to be diluted & may be administered as slow IM or IV inj in not less than 30 sec. The initial dose may be followed by 2 additional IV or IM doses of 8 mg 2-4 hr apart or by constant infusion of 1 mg/hr for up to 24 hr.
Highly emetogenic chemotherapy Max initial dose of 16 mg IV infused over 15 min.
CINV Childn & adolescent (≥2 yr) of 0.6-1.2 m2 5 mg/m
2 as single IV immediately before chemotherapy followed by 4 mg orally 12 hr later. Continue orally w/ 4 mg bd for up to 5 days after a course of treatment.
CINV & RINV Elderly ≥75 yr Max: 8 mg infused over 15 min. Initially 8 mg followed by 2 doses of 8 mg infused over 15 min & given less than 4 hr apart;
65-74 yr Initially 8 or 16 mg infused over 15 min may be followed by 2 doses of 8 mg infused over 15 min & given no less than 4 hr apart.
Prevention of PONV Adult 4 mg as single dose by IM or slow IV inj administered at the induction of anaesth.
Treatment of established PONV 4 mg as single dose by IM or slow IV inj.
Prevention & treatment of PONV Childn & adolescent (≥2 yr) 0.1 mg/kg up to a max of 4 mg administered by slow IV inj (not less than 30 sec) prior to , at or after induction of anaesth or after surgery.
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