Pinazepam


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Anxiety 5-20 mg/day in divided doses. Insomnia associated w/ anxiety 2.5-5 mg at bedtime.
Dosage Details
Oral
Insomnia associated with anxiety
Adult: 2.5-5 mg once daily at night.

Oral
Short-term management of anxiety
Adult: 5-20 mg daily in divided doses.
Renal Impairment
Dose adjustment may be required.
Hepatic Impairment
Dose adjustment may be required.
Administration
May be taken with or without food.
Contraindications
Preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency, myasthenia gravis, sleep apnoea, severe hepatic impairment; not indicated for chronic psychosis, phobic or obsessional states; glaucoma.
Special Precautions
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy, lactation; history of alcohol or drug addiction, hypotension and apnoea with IV admin, therefore this route should only be used when facilities for reversing resp depression are available. Monitor for signs of suicidal tendency or aggressive behavior; not to be used alone to treat depression or anxiety associated with depression.
Adverse Reactions
Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia; rarely, jaundice, blood disorders and hypersensitivity reactions; pain and thrombophloebitis; raised liver enzyme values; paradoxical excitation.
Drug Interactions
Enhanced sedation or resp and CV depression with drugs with CNS depressant properties e.g. alcohol, antidepressants, antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics and cisapride.
Action
Description: Pinazepam is a long-acting benzodiazepine with general properties similar to diazepam.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pinazepam from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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