Posaconazole - intravenous

Patient Medicine Information
Why do I need this medicine?
Posaconazole is used to prevent and treat fungal infections.

This medicine may be used to treat other conditions as decided by your doctor.
How do I use this medicine?
Posaconazole injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Posaconazole.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Do not use this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Posaconazole.

Do not use Posaconazole with medicines to treat migraine, heart disease, high cholesterol level, allergy, stomach problems, mental disorder and malaria. Please see the section “Can I take this with other medicines?” below for more information.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • heart disease e.g. heart rhythm disorder, heart muscle disease
  • liver disease
  • kidney disease
  • body weight of more than 120 kg or less than 60 kg
Let your doctor know if you are pregnant or breastfeeding.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to do routine blood tests (e.g. liver function tests, kidney function tests, complete blood count, and levels of calcium, magnesium, potassium in the blood) before and during treatment with this medicine.
What side effects could I experience?
Posaconazole may cause drowsiness or dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, diarrhoea, nausea, vomiting, stomach pain or discomfort, constipation, loss of appetite, fever, back pain, weakness, difficulty sleeping, chills, mouth sores, rash, itching, and muscle and joint pain.

If you develop rashes, breathlessness, swollen mouth or eyes, stop using the medicine and inform your doctor quickly. These could be signs of an allergic reaction.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

- rashes, breathlessness, swollen mouth or eyes
- frequent and persistent sore throat with fever, unusual bleeding or bruising
- abnormal heart rhythm, muscle spasms
- abnormal eye movements, convulsions
- increased thirst, frequent urination, blurred vision, trouble concentrating

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Do not take this medicine with the following medicines:
  • medicines for migraine e.g. ergotamine, dihydroergotamine
  • medicines for heart disease e.g. quinidine
  • cholesterol-lowering medicines e.g. simvastatin, lovastatin, atorvastatin
  • medicines to treat allergy e.g. terfenadine, astemizole
  • stomach medicines e.g. cisapride
  • medicines to treat mental disorder e.g. pimozide
  • medicines to treat malaria e.g. halofantrine
Inform your doctor and pharmacist if you are taking any of these medicines:
  • other medicines for heart disease e.g. digoxin, diltiazem, nifedipine, verapamil
  • other stomach medicines e.g. cimetidine, esomeprazole
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin, sirolimus, tacrolimus
  • medicines for epilepsy (fits or seizure) e.g. phenytoin
  • medicines used to treat cancer e.g. vinca alkaloids such as vincristine, vinblastine
  • medicines for HIV infection e.g. atazanavir, efavirenz, fosamprenavir, ritonavir
  • medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on posaconazole - intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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