Prasterone


Generic Medicine Info
Indications and Dosage
Vaginal
Dyspareunia
Adult: As pessary: Insert 6.5 mg once daily at bedtime.
Contraindications
Undiagnosed abnormal genital bleeding, history of known or suspected breast cancer.
Special Precautions
Patient with known thromboembolic states, undergone hysterectomy.
Adverse Reactions
Significant: Vaginal discharge.
Investigations: Weight fluctuation.
Reproductive system and breast disorders: Abnormal Pap smear, cervical/uterine polyps, breast mass.
Monitoring Parameters
Perform breast and pelvic exam. Monitor for excessive bleeding or vaginal discharge.
Action
Description: Prasterone is an inactive endogenous steroid. The exact mechanism of action is not fully established, however, it exhibits both androgenic and oestrogenic activity.
Synonym: dehydroepiandrosterone.
Pharmacokinetics:
Metabolism: Metabolised via dehydrogenase, reductase, and aromatase to 2 active metabolites (estradiol and testosterone).
Chemical Structure

Chemical Structure Image
Prasterone

Source: National Center for Biotechnology Information. PubChem Database. Dehydroepiandrosterone, CID=5881, https://pubchem.ncbi.nlm.nih.gov/compound/Dehydroepiandrosterone (accessed on Jan. 23, 2020)

Storage
Store between 5-30°C. Follow applicable procedures for receiving, handling, administration, and disposal.
ATC Classification
A14AA07 - prasterone ; Belongs to the class of androstan derivative anabolic steroids used as systemic anabolic agents.
References
Anon. Prasterone. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com/. Accessed 04/05/2018.

Anon. Prasterone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/05/2018.

Buckingham R (ed). Prasterone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/05/2018.

Intrarosa (Endoceutics Ltd.). European Medicines Agency [online]. Accessed 04/05/2018.

Intrarosa Insert (AMAG Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/05/2018.

Disclaimer: This information is independently developed by MIMS based on Prasterone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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