Tablet containing 75mg Dipyridamole.
Pharmacology: Action: Procardin has an antithrombotic action based on its ability to modify various aspects of platelet function, such as platelet aggregation, adhesion and survival, which have been shown to be factors associated with the initiation of thrombus formation.
Procardin modifies platelet function by enhancing prostacyclin effect through a strong inhibition of phosphodiesterase and mild stimulation of adenyl cyclase formation. It has also been shown to inhibit the formation of thromboxane A2 which is known to cause platelet adhesion and aggregation.
For diseases or conditions where modification of platelet function may be beneficial.
Adults: 300-600mg daily in three or four doses.
Children: The normal total daily dose is 5mg/kg in divided doses. Procardin should usually be taken before meals.
There are no absolute contra-indications to the administration of Procardin.
Procardin is a potent vasodilator and should therefore be used with caution in patients with rapidly worsening angina, subvalvular aortic stenosis or haemodynamic instability associated with a recent sustained myocardial infarction. Although Procardin has been in wide general use for many years there is no evidence of ill-consequence during human pregnancy, animal studies have shown no hazard. Medicines should not be used in pregnancy, especially the first trimester, unless the expected benefit is thought to outweigh any possible risk to the foetus.
If these occur it is usually during the early part of treatment and they are often dose-related. The vasodilating properties of Procardin may occasionally produce a vascular headache which normally disappears with dosage reduction. Dyspepsia has occasionally been reported. Mild diarrhoea is rarely encountered.
Dipyridamole interacts with heparin antiinflammatories/analgesics nonsteroidal, anticoagulants - coumarin or indandione-derivative, azlocillin, carbenicillin, cefamandole, cefoperazone, dextrans, mezlocillin, piperacillin, salicylates, sulfinpyrazone, valproic acid, streptokinase and urokinase.
Store in a well closed container in a cool dry place away from light.
B01AC07 - dipyridamole ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.