Avoid long-term continuous treatment as this may cause atrophic skin changes [leading to thinning, elasticity loss, superficial blood vessels dilatation, telangiectasiae, ecchymoses, urticaria, contact dermatitis (rectal oint only) & rash] especially when occlusive dressings are used. Depression of hypothalamic-pituitary-adrenal axis w/ consequent suppression of adrenal gland may occur (most likely to be severe in childn). Risk of retarded growth; cushingoid state; benign intracranial HTN (rarely). Exclude potential malignancies prior to treatment. If patient presents symptoms eg, blurred vision or other visual disturbances, consider referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases eg, central serous chorioretinopathy. Institute suitable concomitant anti-microbial therapy in the presence of a secondary microbial skin infection. Supp: Anal irritation may occur in patients sensitive to any of the ingredients.