Adverse reactions characterized by either thrombosis or disseminated intravascular coagulation (DIC) are associated with administration of factor IX complex concentrates. In particular, patients who receive prolonged treatment with factor IX complex concentrates postoperatively or with known liver disease should be kept under close observation for signs or symptoms of intravascular coagulation. Continued administration should be left to the discretion of the physician.
Adverse reactions may include urticaria, fever, chills, nausea, vomiting, headache, somnolence, lethargy, flushing or tingling. For most reactive individuals, slowing the rate of infusion relieves the symptoms. For those highly reactive individuals, a different lot may be satisfactory.