Usual doses for duodenal ulcer and benign gastric ulcer patients are 20 mg once daily. Healing can be attained within 4 weeks of treatment (for duodenal ulcer patients) and 8 weeks of treatment (for benign gastric ulcer). Doses can be increased to 40 mg once daily on severe cases.
For the patients with erosive reflux esophagitis, the recommended dosage is 20 mg once daily, given for 4 weeks. For those patients not fully healed after the initial course, healing usually occurs during a further 4-8 weeks of treatment.
For the patients with reflux esophagitis refractory to other therapy, it is used in a dose of 20 mg once daily.
The recommended initial dosage for patient with Zollinger-Ellison syndrome is 60 mg once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated. Patients with severe disease and inadequate response to other therapies have been effectively controlled on doses of 20 - 120 mg daily. With doses above 80 mg daily, the dose should be divided and given twice daily.
Dose adjustment is not required in patients with impaired renal or hepatic function, or in elderly.
There is no experience of the use of Omeprazole in children.