Ranolazine - oral

Patient Medicine Information
Why do I need this medicine?
Ranolazine is used together with other medicines to treat chronic angina (long-term chest pain which occurs when the heart does not receive enough blood and oxygen).
How do I take this medicine?
Take Ranolazine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Ranolazine is available as an extended-release tablet. Swallow it whole. Do not crush, break, or chew the tablet.
What should I do if I have forgotten to take this medicine?
If you miss a dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • moderate or severe liver disease
  • severe kidney disease
as Ranolazine may not be suitable for you.

This medicine is not indicated for sudden episode of chest pain.

Do not take Ranolzaine with certain antibiotics, medicines to treat fungal or HIV infection, depression, heart rhythm disorders, epilepsy (fits or seizures), TB (infection known as tuberculosis), or certain herbal supplements. Please see the section “Can I take this with other medicines?” below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart disease e.g. heart rhythm disorder, heart failure
  • mild liver disease
  • mild to moderate kidney disease
  • low body weight (60 kg or less)
Let your doctor know if you are pregnant or breastfeeding.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. ECG, renal function) may be needed. Your doctor will advise you about how often you will need these tests.
  • You may need to regularly monitor your blood pressure while being treated with this medicine.
What side effects could I experience?
Ranolazine may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects may include any of the following: headache, constipation, nausea, vomiting, weakness.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Ranolazine with the following medicines:
  • certain antibiotics e.g. clarithromycin, telithromycin
  • medicines for fungal infection e.g. itraconazole, ketoconazole, voriconazole, posaconazole
  • medicines for HIV infection e.g. ritonavir, saquinavir
  • medicine to treat depression e.g. nefazodone
  • medicine for heart rhythm disorders e.g. quinidine, dofetilide, sotalol
  • medicines to treat epilepsy e.g. phenytoin, carbamazepine, phenobarbital
  • medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
  • herbal supplement e.g. St. John’s wort
Inform your doctor and pharmacist if you are taking any of these medicines:
  • antibiotic e.g. erythromycin
  • medicine for fungal infection e.g. fluconazole
  • medicines for heart disorder e.g. digoxin, metoprolol, diltiazem, verapamil
  • medicines for allergy e.g. terfenadine, astemizole, misolastine
  • medicines to treat depression e.g. imipramine, doxepin, amitriptyline
  • medicines for HIV infection e.g. efavirenz
  • cholesterol-lowering medicines e.g. lovastatin, simvastatin
  • medicines used in organ transplant or certain immune disorder e.g. ciclosporin, tacrolimus
  • medicine for cancer e.g. cyclophosphamide
This list does not include all medicines that may interact with Ranolazine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol and grapefruit or grapefruit juice.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on ranolazine - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by MIMS.com
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