Rebif

Rebif Description

interferon beta-1a

Manufacturer:

Merck

Distributor:

Apex Pharma Marketing
Full Prescribing Info
Description
Each Rebif 22 micrograms solution for injection in cartridge contains 66 micrograms (18 MIU*) of interferon beta-1a** in 1.5 ml solution, corresponding to 44 micrograms/ml.
*Million International Units, measured by cytopathic effect (CPE) bioassay against the in-house IFN beta-1a standard which is calibrated against the current international NIH standard (GB-23-902-531).
**Produced in Chinese hamster ovary Cells (CHO-K1) by recombinant DNA technology.
Each Rebif 44 micrograms solution for injection in cartridge contains 132 micrograms (36 MIU*) of interferon beta-1a** in 1.5 ml solution corresponding to 88 micrograms/ml.
*Million International Units, measured by cytopathic effect (CPE) bioassay against the in-house IFN beta-1a standard which is calibrated against the current international NIH standard (GB-23-902-531).
**Produced in Chinese hamster ovary Cells (CHO-K1) by recombinant DNA technology.
Rebif has a pH of 3.7 to 4.1 and osmolarity 250 to 450 mOsm/l.
Excipients/Inactive Ingredients: Mannitol, poloxamer 188, L-methionine, 7.5 mg benzyl alcohol, sodium acetate, acetic acid for pH adjustment, sodium hydroxide for pH adjustment, water for injections.
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