Rectogesic

Rectogesic

glyceryl trinitrate

Manufacturer:

Care Pharmaceuticals

Distributor:

Steward Cross
Full Prescribing Info
Contents
Glyceryl trinitrate.
Description
Glyceryl trinitrate, also known as nitroglycerin.
Indications/Uses
Treatment of anal fissure and relief of the symptoms associated with anal fissure.
Dosage/Direction for Use
Adults: Insert a 1-1.5 cm strip of ointment into the anal canal, either with the finger or an applicator. Apply the ointment 3 times daily and do not exceed this dosage.
Overdosage
Headache, fainting or dizziness are the most common indication of overdosage. When these symptoms are observed, discontinue treatment for a minimum of 8 hrs and then the dosage halved. Simple analgesics eg, paracetamol may be helpful for headaches. If headaches are severe and persistent, discontinue administration.
Contraindications
Severe anaemia, glaucoma, hypotension, increased intracranial pressure and idiosyncrasy to glyceryl trinitrate.
Glyceryl trinitrate should not be co-administered with sildenafil citrate (Viagra) and/or other phosphodiesterase type 5 (PDE5) inhibitors as this may potentiate the hypotensive effects of organic nitrates.
Special Precautions
Effects on the Ability to Drive or Operate Machinery: As patients may experience faintness and/or dizziness, particularly the elderly, reaction time when driving or operating machinery may be impaired especially at the start of treatment.
Use in pregnancy: The safety of Rectogesic in pregnancy has not been established. Therefore, Rectogesic should not be given to pregnant women.
Use in lactation: It is not known whether glyceryl trinitrate is excreted in human milk. Therefore, Rectogesic should not be given to lactating women.
Use in children: Safety and effectiveness in children have not been established.
Use In Pregnancy & Lactation
Use in pregnancy: The safety of Rectogesic in pregnancy has not been established. Therefore, Rectogesic should not be given to pregnant women.
Use in lactation: It is not known whether glyceryl trinitrate is excreted in human milk. Therefore, Rectogesic should not be given to lactating women.
Side Effects
Headache is the most common reaction. However, they are usually mild and occur after the first few applications. If headache persists, the dose should be reduced, failing which the treatment should be withdrawn. It may also cause fainting or dizziness particularly in the elderly.
Incontinence is also a possible adverse effect, although this has not been reported and should be completely reversible on withdrawal of the drug.
Drug Interactions
Concomitant use of alcohol may enhance vascular effects.
Concomitant Use with Other Nitrates: If a patient is already using glyceryl trinitrate or other nitrates for cardiac disease then using Rectogesic could potentially cause tachyphylaxis by eliminating nighttime-free interval. Where such tachyphylaxis may cause concern, it is advised that Rectogesic should be used during the day only.
ATC Classification
C05AE01 - glyceryl trinitrate ; Belongs to the class of muscle relaxants. Used in the topical treatment for the treatment of hemorrhoids and anal fissures.
Presentation/Packing
Oint 0.2% x 30 g.
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