Ruxolitinib is used to treat certain type of blood and bone marrow cancer.
Take Ruxolitinib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take it with or without food. Try to take it at the same time each day.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your condition and response to the medication.
Ruxolitinib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
If you missed a dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Do not take Ruxolitinib if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Ruxolitinib may cause harm to your unborn child. You must use proven birth control methods while taking this medicine.
Do not breastfeed while you are being treated with this medicine and for 2 weeks after your last dose.
Inform your doctor if you have the following conditions:
Why is it important to keep my appointments with the doctor?
- liver disease
- kidney disease
- hepatitis B infection
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Pregnancy tests must be done to know if this medicine is suitable for you to take.
- Certain tests (e.g. complete blood count, lipid parameters, liver and kidney function) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs and symptoms of infections may also be needed.
Ruxolitinib may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, tiredness, difficulty sleeping, diarrhoea, constipation, nausea, vomiting, stomach pain, muscle spasm, weight gain, and bleeding from the nose.
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.
Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.
White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.
Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for fungal infection e.g. itraconazole, ketoconazole
- medicines for HIV infection e.g. lopinavir, ritonavir
- certain antibiotics e.g. clarithromycin, telithromycin
- medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenytoin, phenobarbital
- medicines for tuberculosis or TB e.g. rifampicin
- medicines for heart disease e.g. digoxin, diltiazem
- medicine for organ transplant and immune disorders e.g. ciclosporin
- blood thinning medicine e.g. dabigatran
- herbal medicines e.g. St. John’s wort
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Avoid alcohol and grapefruit juice.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.