Possible potentiation of drug side effects w/ local anesth (eg, pacemaker implantation, surgery or dental work) & drugs which have an inhibitory effect on the heart rate &/or myocardial contractility (eg, β-blockers, TCAs). May increase plasma/blood levels of drugs metabolized by CYP2D6 (eg, venlafaxine); propranolol, metoprolol, desipramine, cyclosporine, theophylline & digoxin. Increased levels w/ inhibitors of CYP2D6, CYP1A2 & CYP3A4 (eg, ketoconazole, cimetidine, quinidine, erythromycin & grapefruit juice). Potential for increased plasma conc w/ ritonavir. May affect conduction & repolarization w/ amiodarone. Increased risk of CNS side effects w/ IV lidocaine. Phenobarb (chronic use). Reduced antiarrhythmic efficacy w/ rifampicin. May enhance the efficacy of oral anticoagulants (eg, phenprocoumon, warfarin) resulting in an increased prothrombin time. Elevated plasma levels w/ SSRIs (eg, fluoxetine & paroxetine).