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Indications and Dosage
Oral
Severe invasive amoebiasis Adult: 1.5 g daily as single or in divided doses for 5 days. Child: 30 mg/kg daily for 5 days. Oral Trichomoniasis, Amoebiasis, Giardiasis Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose. |
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Contraindications
Hypersensitivity; pregnancy (1st trimester) and lactation.
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Special Precautions
Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
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Adverse Reactions
Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
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Drug Interactions
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.
Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage. |
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Action
Description: Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
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MIMS Class
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