Senna / Sennosides A & B

Generic Medicine Info
Indications and Dosage
Adult: 15-30 mg (as total sennosides) 1-2 times daily.
Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime.

Bowel evacuation
Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
Special Precautions
Inflammatory bowel disease. Avoid prolonged use.
Adverse Reactions
Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
Description: Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Duration: 6-12 hr.
Absorption: Some absorption following oral admin.
Distribution: Enters the breast milk.
Metabolism: Unabsorbed senna undergoes hydrolysis in the colon to release the active anthraquinones while absorbed senna undergoes hepatic metabolism.
Excretion: Excreted in the urine & faeces.
Disclaimer: This information is independently developed by MIMS based on Senna / Sennosides A & B from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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