Dose escalation: 0.375 mg on wk 1, followed by 0.75 mg on wk 2 & then 1.5 mg on wk 3. Maintenance: 0.375-4.5 mg daily. During dose escalation in pivotal studies both in early & advanced disease, efficacy was observed starting at a daily dose of 1.5 mg. Concomitant levodopa therapy
Dosage of levodopa is reduce during dose escalation & maintenance treatment. Renal impairment CrCl 30-50 mL/min
Initially 0.375 mg every other day, may be increased by 0.375 mg at wkly intervals up to a max of 2.25 mg/day.