Sivextro

Sivextro

Manufacturer:

MSD

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Tedizolid phosphate
Indications/Uses
Acute bacterial skin & skin structure infections (ABSSSI) caused by susceptible isolates of gm +ve microorganisms [Staph aureus (including methicillin-resistant & -susceptible isolates), Strep pyogenes, Strep agalactiae, Strep anginosus group (including Strep anginosus, Strep intermedius, & Strep constellatus), & Enterococcus faecalis.
Dosage/Direction for Use
ABSSSI Patient ≥18 yr Oral 200 mg once daily for 6 days. IV 200 mg once daily over 1 hr for 6 days.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Patients w/ neutropenia (neutrophil counts <1,000 cells/mm3). Consider Clostridium difficile-associated diarrhea (CDAD) in all patients who present w/ diarrhea following antibiotic use; careful medical history as CDAD may occur >2 mth after antibacterial administration. Discontinue antibacterial use (not directed against Clostridium difficile) if CDAD is suspected or confirmed. May increase risk of drug-resistant bacteria development if used in absence of a proven/strongly suspected bacterial infection or prophylaxis. Pregnancy & lactation. Childn <18 yr. Elderly ≥65 yr.
Adverse Reactions
Nausea, headache, diarrhea, vomiting, dizziness.
Drug Interactions
May increase plasma conc of oral breast cancer resistance protein (BCRP) substrates; consider possible treatment interruption especially for BCRP substrates w/ narrow therapeutic index (eg, methotrexate or topotecan); monitor AR related to the concomitantly administered BCRP including rosuvastatin if co-administration cannot be avoided.
MIMS Class
Other Antibiotics
ATC Classification
J01XX11 - tedizolid ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Presentation/Packing
Form
Sivextro FC tab 200 mg
Packing/Price
6's
Form
Sivextro lyo powd for soln for infusion 200 mg
Packing/Price
1's
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