Occasional skin rashes and angio-edema have been reported. Nausea, vomiting, abdominal discomfort, epigastric distress, headache, inability to concentrate, insomnia, tinnitus and vertigo may occur. Patients who have exhibited aspirin hypersensitivity in the past may exhibit the same phenomenon on naproxen sodium. Bronchospasm may be precipitated in patients who have history of bronchial asthma or allergic disease. Thrombocytopenia, granulocytopenia, jaundice, peptic ulceration, nephropathy, aplastic anaemia, haemolytic anaemia and hearing impairment may occur.