Spironolactone - oral

Patient Medicine Information
Why do I need this medicine?
Spironolactone is used to treat water retention caused by heart failure, liver or kidney disease. Water retention may be noticed as swelling of the feet, ankles, lower leg and hands, or shortness of breath. For this reason, it is commonly known as a "water pill."

This medicine is also used together with other medicines to keep your blood pressure under control.

Spironolactone may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Spironolactone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine together with food. Try to take it at the same time each day.

You may need to pass urine more often while being treated with Spironolactone. Take this medicine early in the day, preferably in the morning. If your doctor has told you to take it twice a day, take the last dose in the late afternoon. This is to prevent you from waking up frequently at night to go to the toilet.

Spironolactone is available as a tablet or an oral suspension.

If you are taking an oral suspension, shake the bottle well before you take it to ensure that the liquid is evenly mixed. Use the measuring spoon or cup provided to measure your dose.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your condition.

Spironolactone must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by your doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • unable to pass urine
  • high potassium levels in the blood
  • Addison's disease (a rare disorder where the adrenal glands produce insufficient hormones)
  • kidney problem due to diabetes
  • severe kidney disease
as this medicine may not be suitable for you.

Do not give Spironolactone to children with moderate to severe kidney disease.

Do not breastfeed while you are being treated with this medicine.

Do not take Spironolactone with certain medicine for high blood pressure, other similar types of “water pills” and potassium supplements (unless instructed by your doctor). Please see the section “Can I take this with other medicines?” below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • diabetes
  • porphyria (an inherited disorder that causes skin or nervous system abnormalities)
  • abnormal menstrual period or breast enlargement
  • respiratory acidosis (lungs cannot remove enough carbon dioxide produced by the body causing your blood to become too acidic)
  • liver disease
  • mild to moderate kidney disease
Let your doctor know if you are pregnant.

Be sure to check with your doctor or pharmacist before giving this medicine to a child or the elderly. Children and elderly people may be more sensitive to the side effects.

Do not switch between different dosage forms unless instructed by your doctor. This is because different dosage forms may have varying ways of working in your body.

If you are going to have an operation or certain laboratory tests, including minor surgery and dental work, inform your doctor or dentist that you are taking Spironolactone.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. kidney function, blood sugar, uric acid, and electrolyte levels) may be done while you are being treated with this medicine. Your doctor will advise you about how often you will need to have these tests.
  • Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure regularly during treatment.
What lifestyle changes can I make to improve my blood pressure?

Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.
What side effects could I experience?
Spironolactone may cause drowsiness or dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

You may need to pass urine more often while you are being treated with Spironolactone. As your body adjusts to the medicine, this urination effect should also decrease.

Other side effects include any of the following: headache, nausea, vomiting, diarrhoea, feeling confused, hair loss, and skin rash or itching.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • muscle weakness, cramping or numbness; fast or irregular heartbeat, difficulty breathing, tiredness
  • breast enlargement in men
  • rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Spironolactone with the following medicines:
  • eplerenone (medicine for high blood pressure)
  • other similar types of “water-pills” or medicines for water retention e.g. amiloride, triamterene
  • potassium supplements (unless instructed by your doctor)
Inform your doctor and pharmacist if you are taking or using any of these medicines:
  • other medicines for high blood pressure e.g. enalapril, captopril, losartan, valsartan
  • digoxin (medicine for heart disease)
  • NSAIDs (medicines for pain and inflammation) e.g. ibuprofen, mefenamic acid, indometacin, aspirin
  • lithium (medicine for mood disorders)
  • heparin (a blood-thinning medicine)
  • colestyramine (a cholesterol-lowering medicine)
  • carbenoxolone (medicine used to treat mouth or stomach ulcers)
  • chlorpropamide (medicine for diabetes)
This list does not include all medicines that may interact with Spironolactone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Do not take potassium supplements or salt substitutes that contain potassium unless instructed by your doctor.

Avoid taking too much food that is high in potassium, such as orange juice, bananas, or prunes.

Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from light and moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on spironolactone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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