Adult, adolescent & childn >70 kg Initiate at a total daily dose of 40 mg & increased after a min of 3 days to approx 80 mg. Dose may be increased after 2-4 additional wk to a max of 100 mg.
Adolescent & childn up to 70 kg Initiate at a total daily dose of 0.5 mg/kg & increased after a min of 3 days to 1.2 mg/kg. Dose may be increased after 2-4 additional wk to a max of 1.4 mg/kg or 100 mg, whichever is less.
Patient w/ moderate hepatic impairment Initial & target doses should be reduced to 50% of the normal dose.
Patient w/ severe hepatic impairment Initial & target doses should be reduced to 25% of the normal dose.
Adult, adolescent & childn >70 kg administered w/ strong CYP2D6 inhibitors Initiate at 40 mg/kg/day & only increase to 80 mg/day.
Adolescent & childn up to 70 kg administered w/ strong CYP2D6 inhibitors Initiate at 0.5 mg/kg/day & only increased to 1.2 mg/kg/day.