Treatment of active duodenal & benign ulcers; pathological hypersecretory conditions eg, Zollinger-Ellison syndrome & multiendocrine adenomas. Maintenance therapy for duodenal ulcers.
Dosage/Direction for Use
Duodenal & gastric ulcers 40 mg daily at bedtime for 4-8 wk. Maintenance: 20 mg once daily at bedtime. GERD Initially 20-40 mg bd for 6-12 wk. Zollinger-Ellison syndrome Initially 20 mg 6 hrly. Adult patient w/ moderate (CrCl <50 mL/min) or severe (CrCl <10 mL/min) renal insufficiency May be reduced to ½ the dose or dosing interval may be prolonged to 36-48 hr.
May be taken with or without food.
Moderate or severe renal impairment. Pregnancy. Elderly.