May enhance CNS-depressant effect (eg, resp depression) w/ substances w/ CNS-depressant effects (eg, alcohol, other opioids, sedatives, hypnotics, anti-depressants, sleeping aids, phenothiazines, neuroleptics, anti-histamines, anti-emetics). May enhance pharmacodynamic effect w/ alcohol, concomitant use should be avoided. Coumarin anti-coagulants; paracetamol, acetylsalicylic acid or naltrexone. May increase plasma conc of oxycodone w/ CYP3A4 inhibitors eg, macrolide antibiotics (eg, erythromycin), azole-antifungals (eg, ketoconazole) & PIs (eg, ritonavir). May induce teh metabolism of oxycodone w/ CYP450 inducers (eg, rifampin, carbamazepine & phenytoin).