Infections caused by tetracycline-sensitive organisms. Trachoma & inclusion conjunctivitis. Alternative drug for several infections when penicillin is contraindicated. Adjunctive therapy in amoebiasis & severe acne.
Prolonged use may lead to overgrowth of nonsusceptible organisms including fungi. May depress plasma prothrombin activity. Not to be administered w/ penicillin, antacids. Monitor for dose-related BUN increase. Not recommended in lactation.
Impaired absorption by antacids. May require downward anticoagulant dosage adjustment on patients on anticoagulant therapy. May interfere w/ bactericidal action of penicillins. May render OCs less effective.