Each capsule contains 250mg Tetracycline Hydrochloride.
Uses: As a broad-spectrum antibiotic.
Tetracycline is a broad-spectrum antibiotic.
Tetracycline is indicated in infections caused by the following micro-organisms: Rickettsiae: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers.
Mycoplasma pneumoniae (PPLO, Eaton agent).
Agents of psittacosis and ornithosis.
Agents of lymphogranuloma venereum and granuloma inguinale.
The spirochaetal agent of relapsing fever (Borrelia recurrentis).
The following Gram-negative micro-organisms: Haemophilus ducreyi (chancroid).
Pasteurella pestis and Pasteurella tularensis.
Vibrio comma and Vibrio fetus.
Brucella species (in conjunction with streptomycin).
Because many strains of the following groups of micro-organisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended.
Tetracycline is indicated for treatment of infections caused by the following Gram-negative micro-organisms, when bacteriological testing indicates appropriate susceptibility to the drug: Escherichia coli.
Enterobacter aerogenes (formerly Aerobacter aerogenes).
Mima species and Herella species.
Haemophilus influenzae (respiratory infections).
Klebsiella species (respiratory and urinary infections).
Tetracycline is indicated for treatment of infections caused by the following: Gram-positive micro-organisms when bacteriological testing indicates appropriate susceptibility to the drug: Streptococcus species.
Staphylococcus aureus (skin and soft tissue infections).
When penicillin is contra-indicated, tetracyclines are alternative drugs in the treatment of infections due to: Neisseria gonorrhoeae.
Treponema pallidum and Treponema pertenue (syphilis and yaws).
Fusiformis fusiformis (Vincent's infection).
In acute intestinal amoebiasis, the tetracyclines may be a useful adjunct to amoebicides. In severe acne, the tetracyclines may be useful adjunctive therapy. Tetracyclines are indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.
Inclusion conjunctivitis may be treated with oral tetracyclines or with a combination of oral and topical agents.
Adults: 1 gram daily in divided doses. In certain cases up to 8 x 250mg daily can be given.
Caution: Antacids impair absorption and should not be given concomitantly.
Hypersensitivity to tetracyclines.
Do not use in childhood (up to 8 years) as it may affect teeth (discoloration, enamel hypoplasia).
Do not use in renal impairment or pregnancy.
As with other antibiotics, prolonged use may lead to overgrowth of nonsusceptible organisms, including fungi.
Tetracycline may depress plasma prothrombin activity.
Do not administer with penicillin.
Renal toxicity: Rise in BUN has been reported and it was dose-related.
Results of animal studies indicate that tetracylines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. All tetracyclines form a stable calcium complex in any bone forming tissue. A decrease in the fibula growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every 6 hours. This reaction was shown to be reversible when the drug was discontinued. Tetracyclines are present in the milk of lactating women who are taking a drug in this class. Therefore the use of tetracycline in pregnancy and lactation is not recommended.
Tetracycline capsules may cause anorexia, nausea, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis, skin rashes, photosensitivity.
Urticaria, anaphylaxis (very rare).
Haemolytic anaemia, thrombocytopenia, neutropenia.
Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of penicillins, it is not advisable to administer these drugs concomitantly. Concurrent use of tetracylines with oral contraceptives may render oral contraceptives less effective. Breakthrough bleeding has been reported.
Store in a cool and dry place protected from light.
J01AA07 - tetracycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Tetracycline-MC cap 250 mg
100 × 10's