Ticagrelor is used together with other medicines to prevent and reduce the risk of heart attack and stroke in people who have a high risk of getting them. This includes people who have had a heart attack or unstable angina (chest pain that is not well controlled). It also includes people with blood circulation problems that may increase their chances of getting a heart attack or stroke.
Take Ticagrelor exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
If you have difficulty swallowing tablet(s), you may crush the tablet(s) and mix it with half glass of water, stir and drink immediately.
Ticagrelor must be taken regularly for it to work well. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- stomach or gut ulcers, especially if you have bled from these ulcers
- severe liver disease
- stroke or history of stroke caused by bleeding in the brain
as Ticagrelor may not be suitable for you.
Do not take this medicine with certain medicines for depression, fungal infections, antibiotics and HIV infection. Please see the section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have:
- heart disease
- kidney disease
- asthma or other lung problem or breathing difficulties
- high uric acid levels in your blood or gouty arthritis
Let your doctor know if you are pregnant or breastfeeding.
If you are going for an operation, including minor operations and dental work, inform your doctor or dentist that you are taking Ticagrelor.
Do not participate in activities in which you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).
Ticagrelor may make you dizzy. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: nosebleeds, bruising, fever, tiredness and headache.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- unusual bleeding, especially excessive bleeding or bleeding that takes a long time to stop
- unusual bruises, especially if the bruises appear by themselves or if they cover a large area
- difficulty breathing
- severe stomach pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Ticagrelor if you are taking any of these medicines:
- ketoconazole (medicine to treat fungal infections)
- clarithromycin (antibiotic)
- nefazodone (medicine for depression)
- medicines to treat HIV infections e.g. ritonavir, atazanavir
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for high cholesterol e.g. simvastatin, lovastatin
- rifampicin (antibiotic)
- medicines for seizure (fits or epilepsy) e.g. phenytoin, carbamazepine, phenobarbital
- digoxin (medicine for heart disease)
- ciclosporin (a medicine used for organ transplant)
- aprepitant (medicine for vomiting)
- cisapride (a medicine used to treat heartburn)
- ergot alkaloids (medicines used to treat migraines)
This list does not include all medicines that may interact with Ticagrelor.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.