Trichlormethiazide


Generic Medicine Info
Indications and Dosage
Oral
Hypertension
Adult: 1-4 mg daily alone or with other antihypertensives.
Child: >6 mth: 70 mcg/kg daily in 1 or 2 divided doses.

Oral
Oedema
Adult: 1-4 mg daily or intermittently.
Contraindications
Severe renal impairment; anuria; Addison's disease; hypercalcaemia; porphyria.
Special Precautions
Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM; SLE; severe heart failure; renal impairment. Monitor blood glucose concentrations in patients taking antidiabetics. Elderly.
Adverse Reactions
Electrolyte imbalance (e.g. hypochloraemic alkalosis, hyponatraemia, and hypokalaemia); hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
Overdosage
Management: Activated charcoal may be used if presented within 1 hr of ingestion. Treatment is symptomatic and aimed at fluid and electrolyte replacement.
Drug Interactions
Increased neuromuscular blocking action of competitive neuromuscular blockers such as atracurium. Increased risk of hypokalaemia with corticosteroids, corticotropin, β2agonists e.g. salbutamol, carbenoxolone, amphotericin B or reboxetine. Increased risk of hypotension with other antihypertensives, alcohol, barbiturates or opioids. Reduced antihypertensive effects with corticosteroids, NSAIDs or carbenoxolone. Increased risk of nephrotoxicity with NSAIDs. Increased requirement of hypoglycaemics in diabetic patients.
Potentially Fatal: Increased risk of lithium and digoxin toxicity with concurrent use. Increased risk of arrhythmias with drugs that prolong the QT interval e.g. astemizole, terfenadine, halofantrine, pimozide and sotalol.
Action
Description: Trichlormethiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of Na and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Onset: 2 hr.
Duration: 24 hr.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Trichlormethiazide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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