In adult, begin infusion of dopamine solution at doses of 2 to 5 μg/Kg per minute. In more severe cases, administration may be initiated at a rate of 5 μg/Kg per minute and increased gradually in 5- to 10 μg/Kg per minute increments up to a rate of 20 to 50 μg/Kg per minute as needed. Dose can be controlled according to condition of patients.
The venous pressure and the lobular pressure should be restored to 10 to 15 cmH2O and 14 to 18 mmHg with a suitable plasma expander or whole blood, prior to administration of dopamine hydrochloride.
If doses in excess of 50 μg/Kg per minute are required, it is advisable to check urine output frequently.
Preparation of infusion solutions: Dopamine Hydrochloride can be diluted with 250ml or 500ml of the following i.v. solutions: 0.9% Sodium Chloride injection, 5% Dextrose, 5% Dextrose and 0.9% Sodium Chloride injection, 5% Dextrose diluted with 0.45% Sodium Chloride injection, 5% Dextrose diluted with Ringer solution containing Sodium Lactate, Compound Sodium Lactate (Hartmann's) Solution, Ringer solution containing Sodium Lactate.