Do not inject by the intravascular route.
Syncope (fainting) can occur following, or even before, any vaccination as a psychogenic response to the needle injection, especially in adolescents. This may be accompanied by several neurological signs such as transient sight disorders, paraesthesia and tonic-clonic limb movements during the recovery phase. It is important that procedures be in place to avoid any injury from faints.
This vaccine protects against the risks of infection by Salmonella typhi but not against Salmonella paratyphi A or B or non-typhoidal salmonella.
The immunogenicity of TYPHIM Vi may be reduced by immunosuppressive treatment or immunodeficiency. It is then recommended to wait until the end of the treatment or disease before vaccinating. Nevertheless, vaccination of subjects with chronic immunodeficiency such as HIV infection is recommended even if the immune response may be limited.
Injection must be performed via the subcutaneous route in subjects with thrombocytopenia or bleeding disorders.
As with all injectable vaccines, appropriate medical treatment and supervision must always be readily available, in the event of a rare anaphylactic reaction following administration of the vaccine.
Effects on ability to drive and use machines: The effects on the ability to drive and use machines have not been studied.
Use in Children: This vaccine is not indicated in children under 2 years of age because of the risk of insufficient antibody response.