Patients for whom hemostatic management is difficult: intracranial hemorrhage, hemoptysis, retroperitoneal hemorrhage and the like.
Patients having undergone intracranial or spinal surgery or with such injury (in the last 2 months).
Patients with aneurysm.
Patients with serious disturbances of consciousness.
Contraindications as a general rule: This product is contraindicated in the following patients, as a general rule. If essential, however, it can be administered with caution.
Patients with atrial fibrillation (particularly with mitral stenosis), patients with infective endocarditis, patients with old myocardial infarction, and patients with a prosthetic valve.
Patients with neurological signs and symptoms of stroke which became complete instantaneously.
Careful Administration: Patients with hemorrhage: under surgical treatments such as operations (including hepatic, renal biopsies), hemorrhagic oculopathy such as diabetic hemorrhagic retinopathy, hemorrhage of the digestive tract, hemorrhage of the urinary tract, abortion or premature delivery, immediately after child delivery, during menstruation, and the like.
Patients with possible hemorrhage: ulcers of the digestive tract, diverticulitis of the digestive tract, colitis, serious hypertension, active tuberculosis, a history of intracranial hemorrhage and the like.
Patients receiving treatment with anticoagulants.
Patients with serious hepatic or renal disturbances.
Patients with intractable hypocoagulability: coagulation factor deficiency, thrombocytopenia, and the like.
Elderly patients (Refer to Administration to elderly patients under Precautions).
Patients with a history of hypersensitivity to this product or tissue culture urokinase.