Disorders related to progesterone deficit. Menstrual irregularities due to ovulation disorders or anovulation; premenstrual disorders; breast pain or benign breast disorders (mastopathies); bleeding (due to fibroma); therapy of the menopause (adjunctive use w/ estrogen in post-menopausal women for prevention of endometrial hyperplasia); menace of preterm delivery & can be used up to 36 wk of pregnancy; threatened miscarriage or prevention of habitual miscarriage due to luteal phase deficiency up to the 12th wk of pregnancy; subfertility or primary or secondary infertility related to progesterone insufficiency in particular in in vitro fertilization cycles &/or oocyte donation.
Progesterone insufficiency 200-300 mg divided into 1 or 2 intakes (100 mg in the morning & 100 mg or 200 mg at bedtime). Threatened abortion 200-400 mg daily until 12th wk of pregnancy. Menace of preterm delivery 400 mg 6-8 hrly during the acute phase depending on the clinical response, then 200 mg tds as maintenance treatment until 36th wk of pregnancy. Hormone replacement therapy in post-menopausal women receiving estrogen therapy Continuously or sequentially for at least 12 days/mth.
Not for the treatment of all cases of spontaneous premature abortion. Not suitable for use as contraceptive. May affect ability to drive or operate machinery. Pregnancy & lactation.
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