Zoladex/Zoladex LA

Zoladex/Zoladex LA

goserelin

Manufacturer:

AstraZeneca

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Goserelin acetate
Indications/Uses
Management of prostate cancer for hormonal manipulation; endometriosis including alleviation of symptoms eg, pain & reduction of the size & number of endometrial lesions. Zoladex Management of breast cancer in pre- & perimenopausal women suitable for hormonal manipulation. Prethinning of the uterine endometrium prior to endometrial ablation or resection. Conjunction w/ Fe therapy in haematological improvement of anaemic patients w/ uterine fibroids prior to surgery; assisted reproduction. Zoladex LA Management of fibroids including shrinkage of lesions, improvement of patient's haematological status & reduction of symptomes eg, pain. Adjunct to surgery.
Dosage/Direction for Use
Zoladex depot inj Adult 1 depot SC into the anterior abdominal wall every 28 days. Assisted reproduction 1 depot to downregulate pituitary gland. Endometriosis Duration of treatment: 6 mth. Endometrial thinning 2 depot administered 4 wk apart w/ surgery timed between 0 & 2 wk after the 2nd depot. Anaemic women due to uterine fibroids 1 depot w/ supplementary Fe for up to 3 mth before surgery. Zoladex LA depot inj Adult men 1 depot SC into the anterior abdominal wall every 3 mth. Adult women 1 depot SC into the anterior abdominal wall every 12 wk.
Contraindications
Hypersensitivity to goserelin acetate or other LHRH analogues. Pregnancy & lactation.
Special Precautions
Men at risk of developing ureteric obstruction or spinal cord compression. May cause reduction in bone mineral density. Preexisting DM. Prolonged treatment in benign gynaecological conditions >6 mth. Increased risk of MI & sudden cardiac death reported in men. Not indicated for use in childn. Zoladex Women w/ metabolic bone disease. May increase uterine cervical resistance. Ovarian hyperstimulation syndrome w/ concomitant gonadotropin. Assisted reproduction regimens in patients w/ polycystic ovarian syndrome. Zoladex LA Female. Return of menses after cessation of therapy may be prolonged.
Adverse Reactions
Decreased libido; hot flush; hyperhidrosis, acne; erectile dysfunction; vulvovag dryness, breast enlargement; inj site reactions. Impaired glucose tolerance, mood swings, altered mood depression; paraesthesia, spinal cord compression; cardiac failure, MI; abnormal BP; rash; bone pain; gynaecomastia; inj site reaction; decreased bone density, increased wt.
Drug Interactions
Drugs known to prolong QT interval or drugs able to induce Torsade de pointes.
ATC Classification
L02AE03 - goserelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Presentation/Packing
Form
Zoladex depot inj 3.6 mg
Packing/Price
1's
Form
Zoladex LA depot inj 10.8 mg
Packing/Price
1's
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