News &amp; Updates

A recent study has found a higher prevalence of falls and fractures in prostate cancer patients receiving enzalutamide relative to those reported in previous clinical trials and postmarketing research.

Prostate cancer patients on enzalutamide may be at risk of fall, fracture

Lowering BP threshold to 130/80 mm Hg enhances hypertension diagnosis

A significant number of masked, sustained, and nighttime hypertension may not be detected when using the conventional home blood pressure (BP) threshold of 135/85 mm Hg, suggests a study.

Lowering BP threshold to 130/80 mm Hg enhances hypertension diagnosis

24 Apr 2026

Maternal obesity may elevate bile acids in breast milk

Maternal obesity appears to increase bile acid (BA) levels in breast milk, which may have implications for neonatal digestion, maturation, and health.

Maternal obesity may elevate bile acids in breast milk

Statin-ezetimibe holds slight advantage over PCSK9is in ACS

In a systematic review and network meta-analysis (NMA), a statin-ezetimibe combination yields a more favourable LDL-C reduction and a positive trend in atherosclerotic plaque regression compared with PCSK9 inhibitors (PCSK9is) alone in individuals with acute coronary syndrome (ACS).

Statin-ezetimibe holds slight advantage over PCSK9is in ACS

24 Apr 2026

16-year HK study: Borderline personality disorder ups risks of physical diseases and mortality

Borderline personality disorder (BPD) is associated with higher risks of a wide range of physical diseases and increased mortality from all causes, natural causes, and external causes, according to a 16-year population-based cohort study in Hong Kong.

16-year HK study: Borderline personality disorder ups risks of physical diseases and mortality

SONIA: Does 1L vs 2L use of CDK4/6 inhibitors improve OS in HR+, ERBB2- ABC?

A phase III randomized clinical trial (RCT) of 1,050 patients with hormone receptor–positive (HR-positive), ERBB2-negative advanced breast cancer (ABC) showed that first-line (1L) use of cyclin-dependent kinase (CDK) 4 and 6 inhibitors did not improve overall survival (OS) compared with second-line (2L) use. At the same time, a post hoc subgroup analysis suggested an OS benefit with 1L use of CDK4/6 inhibitors in premenopausal patients.

SONIA: Does 1L vs 2L use of CDK4/6 inhibitors improve OS in HR+, ERBB2- ABC?

24 Apr 2026

Pulsed field ablation helps prevent atrial tachyarrhythmia recurrence

Pulsed field ablation (PFA) appears to reduce atrial tachyarrhythmia recurrence, and its use tends to lead to fewer redo ablations, a study in the Philippines has shown.

Pulsed field ablation helps prevent atrial tachyarrhythmia recurrence

GLP-1RAs offer histologic benefits in MASH without fibrosis progression

23 Apr 2026 by

Treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and liraglutide, improves histologic outcomes in patients with biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) without compromising safety, reports a Singapore study.

GLP-1RAs offer histologic benefits in MASH without fibrosis progression

Age, comorbid SUDs modify mental health risks linked to cannabis use disorder

Mental health risks associated with cannabis use disorder (CUD) differ by age and comorbid substance use disorders (SUDs), suggests a study.

Age, comorbid SUDs modify mental health risks linked to cannabis use disorder