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Obefazimod hits targets in identical trials on active UC

31 Dec 2025 by

Two phase III induction trials have demonstrated the efficacy and safety of obefazimod, an oral, first-in-class, small molecule, for the treatment of adults with moderate-to-severe ulcerative colitis (UC).

Obefazimod hits targets in identical trials on active UC

31 Dec 2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-November-2025

31 Dec 2025

New drug applications approved by US FDA as of 1-15 November 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-November-2025

31 Dec 2025

Lubiprostone use heightens risk of headache

30 Dec 2025

Treatment with lubiprostone is associated with an increased risk of headache in adults and children, according to a recent meta-analysis.

Lubiprostone use heightens risk of headache

30 Dec 2025

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025 by

Treatment with mitapivat increased haemoglobin (Hb) levels in children with pyruvate kinase (PK) deficiency who were not receiving regular blood transfusions, according to the ACTIVATE-Kids trial presented at ASH 2025.

Mitapivat improves Hb levels in paediatric patients with PK deficiency

30 Dec 2025

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025 by

In a subgroup analysis of patients with paroxysmal nocturnal haemoglobinuria (PNH) with a history of aplastic anaemia and concomitant immunosuppressive therapy (AA + IST), long-term treatment with iptacopan yields clinically meaningful improvements in haemoglobin levels, transfusion needs, and haemolysis control, with safety outcomes comparable to those in individuals without AA.

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

29 Dec 2025

What is the best intervention for fever-related discomfort in children?

28 Dec 2025 by

In children with fever-associated discomfort, pharmacological interventions appear safe and effective, while physical methods provide limited benefits, suggest the results of a systematic review.

What is the best intervention for fever-related discomfort in children?

28 Dec 2025

Interprofessional collaboration resolves drug-related problems in home care services in SG

24 Dec 2025 by

Collaborations among pharmacists, physicians, and nurses in home care results in significant improvements in identifying and resolving drug-related problems (DRPs), a Singapore study has shown.

Interprofessional collaboration resolves drug-related problems in home care services in SG

24 Dec 2025

Multidrug combos provide optimal glycaemic control in T2D patients

24 Dec 2025 by

A real-world study from India shows that multiple drug combinations effectively controlled blood sugar levels in individuals with type 2 diabetes (T2D).

Multidrug combos provide optimal glycaemic control in T2D patients

24 Dec 2025

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

24 Dec 2025 by

Inhaled Technosphere insulin significantly reduced HbA_1c levels in Indian individuals with type 2 diabetes (T2D) compared with placebo, according to a study presented at ATTD-ASIA 2025.

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

24 Dec 2025

Adjunctive lumateperone improves symptoms in major depressive disorder

23 Dec 2025

Lumateperone plus antidepressant therapy (ADT) demonstrates clinically meaningful improvements in depression symptoms and disease severity relative to placebo plus ADT, according to a study.

Adjunctive lumateperone improves symptoms in major depressive disorder

23 Dec 2025

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Obefazimod hits targets in identical trials on active UC

Obefazimod hits targets in identical trials on active UC

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-November-2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-November-2025

Lubiprostone use heightens risk of headache

Lubiprostone use heightens risk of headache

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Mitapivat improves Hb levels in paediatric patients with PK deficiency

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

Subgroup analysis shows durable efficacy, safety of iptacopan for PNH treatment

What is the best intervention for fever-related discomfort in children?

What is the best intervention for fever-related discomfort in children?

Interprofessional collaboration resolves drug-related problems in home care services in SG

Interprofessional collaboration resolves drug-related problems in home care services in SG

Multidrug combos provide optimal glycaemic control in T2D patients

Multidrug combos provide optimal glycaemic control in T2D patients

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

Inhaled Technosphere insulin lowers HbA1c in Indian patients with T2D

Adjunctive lumateperone improves symptoms in major depressive disorder

Adjunctive lumateperone improves symptoms in major depressive disorder