Bronchitis%20-%20chronic%20in%20acute%20exacerbation Signs and Symptoms

Signs and Symptoms

Definition

Chronic bronchitis is a clinical diagnosis of sputum expectoration on most days during at least three consecutive months for ≥2 consecutive years

Signs and Symptoms

Symptoms of exacerbation are increase in dyspnea, sputum volume and sputum purulence over baseline

Risk Factors for Exacerbations

Tracheobronchial infections (eg influenza, streptococcal infection)
Environmental or inhalational exposures (eg air pollution, smoking)
Noncompliance with inhaled bronchodilator therapy or pulmonary rehabilitation program

Challenges in the diagnosis and management of multidrug-resistant gram-negative infections: Real-world evidence and experience

Prof. David Paterson, Dr. Asok Kurup, 02 Nov 2022

The diagnosis and treatment of multidrug-resistant (MDR) gram-negative bacteria in critically ill patients present many clinical challenges. Selection of appropriate antibiotic therapy in a timely manner requires patients’ comprehensive medical history, updated local knowledge of microbiological epidemiology, efficient use of diagnostic tools, and balancing of information from clinical trial data, real-world evidence (RWE), and guidelines.

In a symposium Pfizer organized in conjunction with the Asia Pacific Intensive Care Symposium (APICS), Professor David Paterson from the National University of Singapore discussed the importance of RWE in the antibiotic armamentarium, using ceftazidime-avibactam (CAZ-AVI, Zavicefta^®) as an example. Dr Asok Kurup, Consultant Infectious Diseases Physician at Mount Elizabeth Medical Centre, Singapore, explained how rapid diagnostics can guide treatment choices to improve patient outcomes in MDR gram-negative infections.

Real-world insights on comparative effectiveness of mRNA COVID-19 boosters

03 Oct 2023

Two target trials were emulated to compare the effectiveness of third doses of mRNA-based COVID-19 vaccines among US veteran population and across at-risk US veteran populations.

Management of allergic rhinitis – focus on Bilaxten

14 Jan 2022

Allergic rhinitis can induce two types of symptoms in patients: i) histamine-mediated symptoms such as vasodilatation, rhinorrhoea, itching and sneezing, and ii) allergic inflammation resulting from the action of eosinophils in the nasal lining. H1-antihistamine therapy is a mode of therapy that seeks to mitigate the histamine-mediated symptoms of allergic rhinitis; this therapy aims to relieve symptoms and to improve quality of life in patients.