Gastroenterology

Top Medical News
Nivolumab plus ipilimumab superior to sunitinib in advanced RCC
Stephen Padilla, 10 hours ago
First-line treatment with nivolumab plus ipilimumab (NIVO+IPI) results in better survival and response benefits in patients with advanced renal cell carcinoma (aRCC) when compared with sunitinib (SUN), as shown by long-term follow-up data from the CheckMate 214 trial.
Pembrolizumab plus lenvatinib effective against nonclear cell RCC
Stephen Padilla, Yesterday
Pembrolizumab (pembro) plus lenvatinib (lenva) provides durable antitumour activity in patients with advanced nonclear cell renal cell carcinoma (nccRCC) and has a manageable safety profile, according to the results of the phase II KEYNOTE-B61 study.
Long-term PPI use linked to higher NAFLD risk
3 days ago
Taking proton pump inhibitors for a long period of time appears to increase the risk of nonalcoholic fatty liver disease (NAFLD), particularly severe hepatic steatosis, reveals a US study.
Contraceptives ease IBD symptoms but induce intestinal inflammation in women
4 days ago
Women with inflammatory bowel disease (IBD) who use hormonal contraceptives (HCs) appear to be less likely to experience IBD-related symptoms but are more likely to have intestinal inflammation over a year, reports a study.
Pembrolizumab delivers long-term survival benefits in advanced esophageal cancer
Stephen Padilla, 6 days ago
First-line pembrolizumab (pembro) plus chemotherapy (chemo) in patients with untreated advanced esophageal cancer demonstrates robust efficacy after 5 years, with no new safety concerns, when compared with placebo plus chemo, according to a study presented at ASCO GI 2024.
Methylnaltrexone proves safety in paediatric oncology patients with constipation
6 days ago
Subcutaneous methylnaltrexone is safe to use in children with cancer who have opioid-induced constipation, suggest the results of a study. In addition, this agent stimulates bowel movements in more than a third of paediatric patients.
Does hand grip strength correlate with clinical disease activity in CD?
Audrey Abella, 23 Feb 2024
Hand grip may be associated with clinical disease activity in patients with Crohn’s disease (CD), but hand grip measurements alone may not be the best predictor of disease activity or related disability, suggests a study presented at Crohn’s and Colitis Congress 2024.
Special Reports
Long COVID: What we have learned so far
Prof. Ghassan Dbaibo, 27 Apr 2023

The WHO defines long COVID as a condition that occurs 3 months from COVID-19 onset, whose symptoms last ≥2 months and cannot be attributed to an alternative diagnosis. In an interview with MIMS Doctor, Professor Ghassan Dbaibo of the Center for Infectious Diseases, American University of Beirut, Beirut, Lebanon, describes the evolving attitudes towards long COVID among healthcare professionals (HCPs), some unexpected predisposing factors, potential biological mechanisms behind prolonged symptom duration and shares data on vaccination’s protective effects against long COVID.

Oral anticoagulant therapy for acute VTE in obese patients
Adjunct Assistant Prof. Pankaj Kumar Handa, 03 Apr 2023
Although direct-acting oral anticoagulants (DOACs) are widely recommended for first-line treatment of venous thromboembolism (VTE), their use in obese patients remains controversial due to the limited representation of such patients in clinical trials. As the prevalence of obesity continues its upward trend, clinicians increasingly have to make treatment decisions for obese patients. MIMS Doctor interviewed Adjunct Assistant Professor Pankaj Kumar Handa, Senior Consultant at Tan Tock Seng Hospital, Singapore, to gain his perspectives on oral anticoagulation in obese patients.
Apixaban may be the DOAC of choice for AF patients at risk for GI bleeding
Dr. Teo Wee Siong, 21 Jan 2023
While current guidelines recommend using direct oral anticoagulants (DOACs) over warfarin in patients with non-valvular atrial fibrillation (NVAF), there is a lack of head-to-head trial data to guide the choice of DOAC. Esteemed expert Dr Teo Wee Siong, Consultant Cardiologist & Cardiac Electrophysiologist from Mount Elizabeth Medical Centre, Singapore, reviewed the latest data on the comparative effectiveness and safety of DOACs in AF, provided valuable insights on considerations for the selection of DOACs, and shared his clinical experience with apixaban (Eliquis, Pfizer).

Optimizing anticoagulation therapy for atrial fibrillation with prior gastrointestinal bleeding
Dr. Pipin Kojodjojo, 24 Jul 2022
Long-term anticoagulation therapy is often recommended for patients with atrial fibrillation (AF) to reduce their risk of stroke, but gastrointestinal bleeding (GIB) is a common complication that presents a significant challenge. Patients with a history of GIB have heightened risks of recurrent bleeding events, hence interruption or discontinuation of anticoagulants is often warranted. When and how to restart anticoagulant therapy following an episode of GIB has been debated. MIMS Doctor interviewed Dr Pipin Kojodjojo, Cardiologist and Cardiac Electrophysiologist at Asian Heart & Vascular Centre, Singapore, to gather his perspectives on how to manage anticoagulant therapy after a GIB episode.
Challenging the status quo: The need for a new gastric acid suppressor
03 Jun 2020
For decades, the treatment of acid-related disorders have been limited to conventional acid suppressants. However, as Dr Daphne Ang (Changi General Hospital, Singapore) explains, clinicians can now maximise acid suppression through newer acid suppressants through potassium competitive inhibition.
Role of Lactobacillus reuteri in managing functional gastrointestinal disorders in infants
Prof. Hania Szajewska, 05 Dec 2019
The three most common functional gastrointestinal (GI) disorders are regurgitation, infantile colic, and constipation. At a recent symposium, Professor Hania Szajewska from the Department of Paediatrics at the Medical University of Warsaw, Poland, discussed the role of probiotics, specifically Lactobacillus reuteri DSM 17938 (Lactobacillus reuteri Protectis) in managing these disorders.
Relationship between tumour response to systemic therapy and overall survival in unresectable hepatocellular carcinoma
Dr Raghav Sundar, 09 Sep 2019

Overall survival (OS) is currently the primary criteria in assessing the efficacy of a cancer treatment. Dr Raghav Sundar, a consultant medical oncologist at the National University Hospital, Singapore, details the crucial role played by tumour response in evaluating treatment efficacy, with a focus on the multiple kinase inhibitor lenvatinib in the treatment of hepatocellular carcinoma (HCC).  

Conference Reports
Pembrolizumab delivers long-term survival benefits in advanced esophageal cancer
Stephen Padilla, 24 Feb 2024
First-line pembrolizumab (pembro) plus chemotherapy (chemo) in patients with untreated advanced esophageal cancer demonstrates robust efficacy after 5 years, with no new safety concerns, when compared with placebo plus chemo, according to a study presented at ASCO GI 2024.
Does hand grip strength correlate with clinical disease activity in CD?
Audrey Abella, 23 Feb 2024
Hand grip may be associated with clinical disease activity in patients with Crohn’s disease (CD), but hand grip measurements alone may not be the best predictor of disease activity or related disability, suggests a study presented at Crohn’s and Colitis Congress 2024.
Thoracoscopic esophagectomy better than open surgery in esophageal cancer
Stephen Padilla, 23 Feb 2024
Thoracoscopic esophagectomy (TE) has demonstrated its noninferiority to open transthoracic esophagectomy (OE) for patients with thoracic esophageal cancer in a study presented at ASCO GI 2024.
Infliximab, vedolizumab similarly effective as 1L Tx for paediatric IBD
Audrey Abella, 22 Feb 2024
In a study presented at Crohn’s and Colitis Congress 2024, infliximab and vedolizumab were found to have similar effectiveness in achiev­ing steroid-free clinical remission (SFCR) and biochemical remission (BR) at 12 months when used as first-line treatment for biologic-naïve paediatric patients with un­complicated mild-to-moderately active inflammatory bowel disease (IBD).
Adalimumab response prevents serious infections in CD
Stephen Padilla, 18 Feb 2024
The risk of developing serious infections is much lower among patients with Crohn’s disease (CD) who showed response to adalimumab therapy than nonresponders, after accounting for disease severity, according to the results of a study presented at CCC 2024.
Does multiple biosimilar switching induce flare in IBD patients?
Stephen Padilla, 17 Feb 2024
Multiple biosimilar infliximab (IFX) switching among patients with inflammatory bowel disease (IBD) does not seem to give rise to disease flares at 12 months compared to those who continued using IFX originator or those on single IFX biosimilar switch, a study has shown.
Saffron serves up benefits for patients with ulcerative colitis
Jairia Dela Cruz, 16 Feb 2024
Saffron supplements show promise in managing ulcerative colitis (UC), with notable effects on inflammatory markers and clinical manifestations of the disease, as reported in a small study.