helicobacter%20pylori%20infection
HELICOBACTER PYLORI INFECTION
Treatment Guideline Chart
Helicobacter pylori is a spiral-shaped Gram-negative bacterium involved in the development of gastritis, duodenal and gastric ulcers, and gastric cancer.
Infection is strongly associated with the development of gastric epithelial and lymphoid malignancies.
Acute infection is mostly asymptomatic and is acquired through human-to-human contact via oral-oral, gastro-oral and fecal-oral routes.
Adaptability in gastric conditions and production of urease allow it to colonize the stomach.

Helicobacter%20pylori%20infection Signs and Symptoms

Definition

Dyspepsia

  • Presence of ≥1 of the following:
    • Bothersome postprandial fullness
    • Early satiation
    • Epigastric pain
    • Epigastric burning
  • No evidence of structural disease that is likely to explain the symptoms
  • Symptoms were present within the last 3 months with onset ≥6 months prior to diagnosis (Rome IV criteria)
  • Though the relationship between functional dyspepsia and Helicobacter pylori (H pylori) is unclear, improvement of functional dyspepsia symptoms was seen with elimination of H pylori infection

Etiology

Helicobacter pylori

  • A spiral-shaped Gram-negative bacterium involved in the development of gastritis, duodenal and gastric ulcers, and gastric cancer
    • H pylori gastritis may decrease or increase acid secretion and cause dyspeptic symptoms  
    • Up to 90-95% of patients with nonsteroidal anti-inflammatory drug (NSAID)-related duodenal ulcers and 80% of patients with non-NSAID-related gastric ulcers are infected
    • Adaptability in gastric conditions and production of urease allow it to colonize the stomach
  • Acute infection is mostly asymptomatic and is acquired through human-to-human contact via oral-oral, gastro-oral and fecal-oral routes
  • Chronic infection is strongly associated with the development of gastric epithelial and lymphoid malignancies
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