Limited data exists on COVID-19 mRNA vaccine
effectiveness in children aged 1–4 years, particularly against Omicron
subvariants. In a cohort study conducted during Omicron XBB subvariant
predominant period in Singapore, completing the primary COVID-19 mRNA vaccine
series significantly protected against COVID-19 infection in this age group,
with 45.2% and 63.3% vaccine effectiveness in partially and fully vaccinated
children, respectively. Vaccine effectiveness was also robust at 74.6% in
children with prior COVID-19 infection who received at least one vaccine dose.
Dr. Chan Kwok Wai Adrian, Prof. Yang Kuang-Yao, 20240110000000
At the 27th Congress of the Asian Pacific Society of Respirology (APSR) 2023, a Pfizer-sponsored symposium addressed the evolving challenges of COVID-19, particularly for patients with pre-existing respiratory conditions. Chaired by Dr Chan Kwok Wai Adrian, a renowned respiratory physician and intensivist from Mount Elizabeth Novena Hospital, Singapore, and featuring insights from Professor Yang Kuang-Yao of National Yang Ming Chiao Tung University, Taipei, Taiwan, the symposium focused on the disease’s impact, treatment guidelines, regional management strategies, and the role of nirmatrelvir/ritonavir, a new oral combination pill, in the treatment of COVID-19.
Assoc Prof. Carolina García-Vidal, Dr. Jasmine Chung, 20240106000000
At a recent symposium organized by Pfizer, in collaboration with the Society of Infectious Disease Singapore, A/Prof Carolina García-Vidal, Senior Specialist, Infectious Diseases Department at Hospital Clínic de Barcelona, Spain, shared valuable insights on managing invasive fungal infections (IFIs) in nontraditional hosts. The session was chaired by Dr Jasmine Chung, Senior Consultant and Director of the Antimicrobial Stewardship Unit, Singapore General Hospital.
Patients with immune-mediated inflammatory diseases face increased COVID-19 risks, but mRNA vaccines offer crucial protection against severe outcomes, including hospitalisation and death, as highlighted by real-world data.
Dermatologists from Asia shared their clinical experience on the use of Janus kinase (JAK) inhibitors in atopic dermatitis (AD) and discussed approaches towards shared patient and doctor decision-making for treatment with JAK inhibitors. Dr Mark Tang (Mount Alvernia Hospital, Singapore) chaired the virtual meeting, which was attended by local dermatologists.
Antibiotic misuse and overuse fuel mutations in bacteria, leading to drug-resistant “superbugs,” with terrifying aftermath. Without intervention, antimicrobial resistance could cause 10 million deaths annually by 2050.
Every year, from November 18–24, the World Antimicrobial Awareness Week highlights these risks and promotes innovative treatments, enhanced surveillance, and best-practice sharing among clinicians. This article offers insights on the use of the fixed-dose combination antibiotic ceftazidime-avibactam in daily hospital settings.
The US Centers for Disease Control and Prevention and the Ministry of Health Singapore recommend a third dose of mRNA-1273 or BNT162b2 COVID-19 vaccine as a part of the primary vaccination course in individuals with moderate to severe immunocompromised (IC) conditions. A recent systematic literature review and pairwise meta-analysis comparing the clinical effectiveness of mRNA-1273 versus BNT162b2 in IC individuals found that mRNA-1273 is associated with better clinical outcomes compared with BNT162b2 in the vulnerable IC populations.