Neurology

Top Medical News
AXS-07 effective migraine treatment in pooled phase III analysis
Elaine Soliven, Yesterday

Treatment with the investigational agent AXS-07 significantly alleviates pain and most bothersome symptoms (MBS) in patients with migraine, according to results of a pooled analysis of the phase III MOMENTUM and INTERCEPT trials presented at AAN 2024.

Dementia common in people with essential tremor
Elvira Manzano, 2 days ago
A prospective cohort study has shown that dementia is more common in individuals with essential tremor than in the general population, highlighting the need to identify those at risk early.
Lower VTE risk seen in atopic dermatitis vs other inflammatory diseases
Stephen Padilla, 2 days ago
Atopic dermatitis (AD) does not seem to induce an increase in the risk of venous thromboembolism (VTE) when considering underlying risk factors, suggests a study. Moreover, patients with AD show a lower VTE risk than those with rheumatoid arthritis (RA), Crohn's disease (CD), ulcerative colitis (UC), psoriatic arthritis (PsA), or ankylosing spondylitis (AS).
Sleep apnoea implicated in cognitive impairment
Jairia Dela Cruz, 4 days ago
People with sleep apnoea tend to also show memory or cognitive symptoms, according to a study, suggesting an association between the sleep-related breathing disorder and cognitive function.
Novel stent works wonders for adults with intracranial aneurysm
Stephen Padilla, 5 days ago
Application of the modified Alpha stent, an intracranial closed-cell stent with a unique mesh design, delivers satisfactory outcomes in coil embolization of unruptured distal internal carotid artery (ICA) aneurysms, reports a study. Its recent adjustment facilitates a less complicated delivery and deployment.
Surgery beneficial to select older adults with epilepsy
6 days ago
Epilepsy surgery may hold promise for carefully selected patients past the age of 50 years, according to a study.
Inactivated vaccine receipt during natalizumab treatment safe, immunogenic in MS patients
17 Apr 2024
For patients with multiple sclerosis (MS) who are receiving treatment with natalizumab, getting shots with inactivated vaccines is safe and immunogenic, with the positive results persisting regardless of the duration of natalizumab therapy, as shown in a study.
Special Reports
Breaking ground in migraine management: First Consensus Guidelines from the Headache Society of Singapore
06 Dec 2023
In a pioneering effort, the Headache Society of Singapore (HSS) has released the first edition of consensus guidelines focusing on the approach to headache disorders and management of migraine. Amid a rapidly growing array of therapeutic options, standardizing treatment approaches is crucial. These guidelines provide a pivotal resource for healthcare professionals navigating the complex landscape of headache disorders, with a special focus on migraine management in adults.
New study unlocks rimegepant benefits for acute migraine
06 Nov 2023

A landmark study conducted in China and South Korea has demonstrated the effectiveness and safety of rimegepant – a groundbreaking orally administered calcitonin gene-related peptide (CGRP) antagonist – for the acute treatment of migraine among adults. [Lancet Neurol 2023;22:476-484] This phase III, double-blind, randomized, placebo-controlled trial marks the first clinical study of a gepant for migraine in China and South Korea, offering promising insights into migraine management.

Updates on migraine management with rimegepant
03 Sep 2023

Migraine is a debilitating neurological condition that affects millions of people worldwide, causing intense headaches, sensory disturbances, and a significant decline in quality of life. Approximately one-third of patients encounter aura, which encompasses transient focal neurological disturbances that precede the attack. [Lancet 2017;390:1211-1259; Headache 2021;61:1021-1039]

Long COVID: What we have learned so far
Prof. Ghassan Dbaibo, 27 Apr 2023

The WHO defines long COVID as a condition that occurs 3 months from COVID-19 onset, whose symptoms last ≥2 months and cannot be attributed to an alternative diagnosis. In an interview with MIMS Doctor, Professor Ghassan Dbaibo of the Center for Infectious Diseases, American University of Beirut, Beirut, Lebanon, describes the evolving attitudes towards long COVID among healthcare professionals (HCPs), some unexpected predisposing factors, potential biological mechanisms behind prolonged symptom duration and shares data on vaccination’s protective effects against long COVID.

Optimizing executive function skills in children: What healthcare professionals should know
Dr. Evelyn Law, 04 Feb 2023
Executive function (EF) skills in childhood predict academic success better than a child’s intelligence quotient (IQ), and are associated with better physical health, more stable careers, and higher socioeconomic status in adulthood. [Psychol Sci 2005;16:939-944; J Clin Psychiatry 2012;73:941-950; Pediatrics 2013;131:637-644] Despite this, EF is an important topic that is often overlooked. To learn more about EF, MIMS Doctor interviewed Dr Evelyn Law, a clinician scientist specialising in developmental and behavioural paediatrics. Dr Law is Assistant Professor at the National University of Singapore Yong Loo Lin School of Medicine, Singapore.
Optimal protection in geriatric patients with atrial fibrillation: An expert’s perspective
Prof. Olivier Hanon, 01 Apr 2022
Geriatric patients with atrial fibrillation (AF) are at increased risk of blood clots that can lodge in the brain and cause fatal strokes. At a recent webinar, Professor Olivier Hanon, Head of Geriatrics Department in Broca Hospital, Paris, France, shared insights on how to optimally protect geriatric patients with AF, with a special focus on direct oral anticoagulants (DOACs), particularly rivaroxaban, for stroke prevention in AF.
Addressing the unmet needs and challenges in managing older AF patients
Dr. Tan Vern Hsen, Dr. Barbara Helen Rosario, 01 Apr 2022
A key focus in the management of atrial fibrillation (AF) in older patients is stroke prevention through oral anticoagulation. However, a significant proportion of older AF patients remain undercoagulated due to the perceived bleeding risk of oral anticoagulants (OACs). Dr Tan Vern Hsen, Senior Consultant, Department of Cardiology, Changi General Hospital, Singapore, and Dr Barbara Helen Rosario, Senior Consultant, Department of Geriatric Medicine, Changi General Hospital, Singapore, shared their respective insights into managing older AF patients for an integrated approach.
Conference Reports
AXS-07 effective migraine treatment in pooled phase III analysis
Elaine Soliven, 24 Apr 2024

Treatment with the investigational agent AXS-07 significantly alleviates pain and most bothersome symptoms (MBS) in patients with migraine, according to results of a pooled analysis of the phase III MOMENTUM and INTERCEPT trials presented at AAN 2024.

Dementia common in people with essential tremor
Elvira Manzano, 23 Apr 2024
A prospective cohort study has shown that dementia is more common in individuals with essential tremor than in the general population, highlighting the need to identify those at risk early.
Sleep apnoea implicated in cognitive impairment
Jairia Dela Cruz, 20 Apr 2024
People with sleep apnoea tend to also show memory or cognitive symptoms, according to a study, suggesting an association between the sleep-related breathing disorder and cognitive function.
Dementia risk threefold higher in the first year after a stroke
Elaine Soliven, 23 Feb 2024

Stroke survivors were more likely to develop dementia within the first year following their stroke than the general population and people with acute myocardial infarction (MI), according to a study presented at ISC 2024.

Reteplase a good alternative to alteplase in acute ischaemic stroke
Stephen Padilla, 20 Feb 2024
Treatment with reteplase appears more effective than alteplase in patients with acute ischaemic stroke (AIS) who have been treated within 4.5 hours of symptom onset, according to the results of RAISE, a phase III multicentre, open-label, randomized controlled, noninferiority trial.
Earlier anticoagulation reversal tied to improved survival in ICH patients
Audrey Abella, 20 Feb 2024
In anticoagulation-associated intracerebral haemorrhage (ICH), earlier administration of reversal treatments is associated with reduced in-hospital mortality or discharge to hospice, according to data presented at ISC 2024.
AI helps improve care quality in stroke patients
Stephen Padilla, 19 Feb 2024
Use of artificial intelligence (AI) as part of the support system can greatly improve the quality of care in patients who just had a stroke and may even prevent the occurrence of various vascular events in the future, according to a study presented at ISC 2024.