Head and neck cancers encompass a wide spectrum of disease, ranging from carcinomas of the upper aerodigestive tract (oral cavity, pharynx, larynx), to tumours of the skin and salivary glands, to sinonasal malignancies.
Systemic therapy plays a central role in the management of unresectable hepatocellular carcinoma (HCC). In this rapidly developing therapy area, recent clinical trials are redefining systemic treatments, including multiple kinase inhibitors (MKI). During the recent Gastro Lunch and Learn sessions sponsored by Eisai, Dr David Tai and Dr Yong Wei Peng discussed the evidence behind MKIs such as lenvatinib (Lenvima®) in the treatment of unresectable HCC through a case-based approach.
Nasopharyngeal cancer (NPC) is a disease in which cancer cells develop from the tissues of the nasopharynx – an area located behind the nose, just above the back of the throat. Chinese from endemic regions such as Hong Kong and Southern China have the highest risk of getting NPC. NPC is the ninth most common cancer among men in Singapore with the highest incidence in Chinese followed by Malays and is rare among Indians. [Singapore Cancer Registry Annual Registry Report, Trends in Cancer Incidence in Singapore 2015]
Dr. Bryan Li, Dr. Gerry Kwok, Dr. Thomas Yau, 20190807035449
Case 1: A 59-year-old gentleman with advanced HCC was referred to our centre for management. He had a history of diabetes, hypertension and ischaemic heart disease. He was a nondrinker and not a carrier of hepatitis B or C.
Case 2: A 65-year-old man with a history of alcoholic cirrhosis and oesophageal varices was found to have rising AFP levels on routine follow-up. He also had a 3-year history of diabetes and was on diet control, with an HbA1cof 6.2 percent and fasting glucose of 6.8 mmol/L. He did not need any diabetic medications.
The eighth most common cancer among women in Singapore, the incidence of thyroid cancer has increased exponentially in the past decades. Fortunately, the most common types of thyroid cancer carry an excellent prognosis and are rarely the cause of mortality if detected early and treated.