Paediatrics

Top Medical News
Omalizumab helps reduce allergic reactions to foods in kids
Jairia Dela Cruz, 7 hours ago
In young children with multiple food allergies, a treatment course with omalizumab appears to increase tolerance to peanuts and other common food allergens.
Major adverse kidney events common among young people undergoing CKRT
Yesterday
Almost two-thirds of youths undergoing continuous kidney replacement therapy (CKRT) have major adverse kidney events 90 days after CKRT initiation (MAKE-90), with risk factors including cardiac comorbidity, time to CKRT initiation, and liberation patterns, according to a study.
Betamethasone falls short of reducing neonatal respiratory complications
3 days ago
Administering betamethasone in the late preterm period to pregnant women at risk of delivering prematurely does not appear to reduce the risk of neonatal respiratory distress, according to a study.
Breastfeeding delivers long-term cardiometabolic benefits in offspring
Audrey Abella, 3 days ago
In a secondary analysis of the HAPO FUS*, breastfeeding was found to be associated with lower rate of glucose metabolism disorders in the offspring; however, this association was not seen among the mothers.
High intake of macronutrients ups ADHD risk in children
Stephen Padilla, 4 days ago
Children who have lower intakes of vitamins and mineral and higher intakes of macronutrients are more likely to have attention deficit hyperactivity disorder (ADHD), suggests an Egypt study.
Bacterial codetection tied to better outcomes in ventilated infants with bronchiolitis
Stephen Padilla, 5 days ago
Bacterial respiratory tract infection normally occurs in infants requiring early intubation in the emergency department (ED) for viral bronchiolitis, according to a study. However, respiratory bacterial codetection appears to shorten the duration of mechanical ventilation (MV) and length of stay (LOS) of these patients in the intensive care unit (ICU).
Methylnaltrexone proves safety in paediatric oncology patients with constipation
6 days ago
Subcutaneous methylnaltrexone is safe to use in children with cancer who have opioid-induced constipation, suggest the results of a study. In addition, this agent stimulates bowel movements in more than a third of paediatric patients.
Special Reports
Effectiveness of mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Under 5: A Population-Based Cohort Study
22 Jan 2024
Limited data exists on COVID-19 mRNA vaccine effectiveness in children aged 1–4 years, particularly against Omicron subvariants. In a cohort study conducted during Omicron XBB subvariant predominant period in Singapore, completing the primary COVID-19 mRNA vaccine series significantly protected against COVID-19 infection in this age group, with 45.2% and 63.3% vaccine effectiveness in partially and fully vaccinated children, respectively. Vaccine effectiveness was also robust at 74.6% in children with prior COVID-19 infection who received at least one vaccine dose.
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Long COVID: What we have learned so far
Prof. Ghassan Dbaibo, 27 Apr 2023

The WHO defines long COVID as a condition that occurs 3 months from COVID-19 onset, whose symptoms last ≥2 months and cannot be attributed to an alternative diagnosis. In an interview with MIMS Doctor, Professor Ghassan Dbaibo of the Center for Infectious Diseases, American University of Beirut, Beirut, Lebanon, describes the evolving attitudes towards long COVID among healthcare professionals (HCPs), some unexpected predisposing factors, potential biological mechanisms behind prolonged symptom duration and shares data on vaccination’s protective effects against long COVID.

Optimizing executive function skills in children: What healthcare professionals should know
Dr. Evelyn Law, 04 Feb 2023
Executive function (EF) skills in childhood predict academic success better than a child’s intelligence quotient (IQ), and are associated with better physical health, more stable careers, and higher socioeconomic status in adulthood. [Psychol Sci 2005;16:939-944; J Clin Psychiatry 2012;73:941-950; Pediatrics 2013;131:637-644] Despite this, EF is an important topic that is often overlooked. To learn more about EF, MIMS Doctor interviewed Dr Evelyn Law, a clinician scientist specialising in developmental and behavioural paediatrics. Dr Law is Assistant Professor at the National University of Singapore Yong Loo Lin School of Medicine, Singapore.
Management of multidrug-resistant organisms in paediatric patients: Role of newer antimicrobial agents
Assoc Prof. Louis Grandjean, Adj Asst Prof. Natalie Tan, 01 Jul 2022

The management of multidrug-resistant (MDR) infections in children is complex, with limited studies and a relative lack of approved new antibiotics with paediatric indications.

At a recent Meet-the-Expert session, Dr Louis Grandjean, Consultant in Paediatric Infectious Diseases at Great Ormond Street Hospital and Associate Professor at University College, London, UK, addressed the growing threat of MDR infections in children and discussed treatment strategies and options for management. He focused on ceftazidime-avibactam (CAZ-AVI, Zavicefta®), whose approval in Singapore was recently expanded to include paediatric patients aged 3 months and older.

Adj Asst Prof Natalie Tan, Senior Consultant at KK Women’s and Children’s Hospital, Singapore, chaired this webinar, which was organized by Pfizer under the auspices of the Singapore Paediatric Society and KK Women’s and Children’s Hospital.

Bilastine in children – understanding principles and practice
24 Feb 2022
Allergic rhinitis is the most frequently occurring form of allergy in the world. It has a high burden in childhood, affecting sleep, concentration, and consecutively, learning. Professor Nikolaos Papadopoulos delivered a lecture on the evidence base and clinical experience supporting the use of Bilastine in children at the 11th Singapore Sleep, Allergy and Rhinology conference on 1 October 2020.
Conference Reports
Breastfeeding delivers long-term cardiometabolic benefits in offspring
Audrey Abella, 27 Feb 2024
In a secondary analysis of the HAPO FUS*, breastfeeding was found to be associated with lower rate of glucose metabolism disorders in the offspring; however, this association was not seen among the mothers.
Maternal transplacental transfer of nipocalimab negligible in foetuses, neonates
Audrey Abella, 23 Feb 2024
In the phase II UNITY study, foetuses and neonates whose mums were receiving nipocalimab for early-onset (≤24 weeks gestational age [GA]) severe haemolytic disease of the foetus and newborn (EOS-HDFN) had minimal exposure to the drug.
Experts share essential updates on COVID-19 vaccines
Elvira Manzano, 20 Nov 2023
SARS-CoV-2 continues to evolve into newer variants. Post-Delta, these variants are generally more highly transmissible and immune-evasive, although not more virulent, said Dr Gregory Poland, Mary Lowell Leary Emeritus Professor of Medicine and director of Mayo Vaccine Research Group, Mayo Clinic in Rochester, Minnesota, US, at IDWeek 2023.
Podcast: Professor Flor Munoz discusses the importance of vaccination for pregnant women and children against COVID-19 at IDW
30 Oct 2023
Podcast: Professor Flor Munoz discusses the importance of vaccination for pregnant women and children against COVID-19 at IDWeek 2023
Ritonavir-boosted nirmatrelvir protects older adults against post-COVID conditions
Jairia Dela Cruz, 26 Oct 2023
Treatment with nirmatrelvir/ritonavir helps lower the incidence of post-COVID conditions (PCC) in older adults, according to a large study.
Ceftazidime-avibactam safe, effective in babies with bacterial infections
Stephen Padilla, 20 Oct 2023
Treatment with single or multiple doses of ceftazidime-avibactam (CAZ-AVI) results in favourable clinical outcomes and is well tolerated in hospitalized neonates and young infants with suspected or confirmed bacterial infections, according to a phase IIa study presented at IDWeek 2023.
Bivalent mRNA vaccine confers protection against SARS-COV-2 infection in young children
Elaine Soliven, 18 Oct 2023

Bivalent COVID-19 vaccine conferred protection against SARS-COV-2 infection among children and adolescents aged 5–11 years, according to a recent study presented at IDWeek 2023.