Paediatrics

Top Medical News
Visual impairment tied to heightened risk of suicidal tendencies among teens
9 hours ago
People with visual impairment may have increased suicidal tendencies, and this association is especially pronounced among adolescents, according to the results of a systematic review and meta-analysis.
Psychosocial risks may impair child’s development
Stephen Padilla, 15 hours ago
Adverse childhood experiences (ACEs), financial needs, and other maternal psychosocial hardships can negatively affect the development of children from vulnerable families in Singapore, according to a study.
Chronic Suppurative Otitis Media (luga)
16 hours ago
A recent systematic review and meta-analysis reveals a considerable burden of otitis media (OM) in China that is often overlooked. At present, the most common bacterial pathogen identified is Streptococcus pneumoniae (S pneumoniae).
Supplementation with essential amino acid improves liver health in teen girls with PCOS
Rachel Tang, 2 days ago
Short-term supplementation with a selective essential amino acid (EAA)-containing product significantly improved liver-related outcomes among adolescent girls with polycystic ovarian syndrome (PCOS) in a recent study.
Port-wine birthmark treatment with once-weekly pulsed dye laser works well for infants
Jairia Dela Cruz, 2 days ago
Administering once-weekly pulsed dye laser (PDL) treatments to infants with port-wine birthmark in the first few months of life appears safe and leads to significant improvements in the involved skin areas, as shown in a small retrospective study.
Paediatric-onset immune-mediated inflammatory diseases raise mortality risk
2 days ago
People with paediatric-onset immune-mediated inflammatory diseases (pIMID) have a roughly fourfold increased risk of death in adulthood, as suggested in a study.
Dyslipidaemia persisting into adulthood spells increased heart disease risk
6 days ago
Elevated nonhigh-density lipoprotein cholesterol (non–HDL-C) levels in childhood that persist into adulthood poses an increased risk of cardiovascular disease (CVD), according to a study. But the good news is that the resolution of dyslipidaemic non–HDL-C levels adulthood may help prevent CVD events.
Special Reports
Effectiveness of mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Under 5: A Population-Based Cohort Study
22 Jan 2024
Limited data exists on COVID-19 mRNA vaccine effectiveness in children aged 1–4 years, particularly against Omicron subvariants. In a cohort study conducted during Omicron XBB subvariant predominant period in Singapore, completing the primary COVID-19 mRNA vaccine series significantly protected against COVID-19 infection in this age group, with 45.2% and 63.3% vaccine effectiveness in partially and fully vaccinated children, respectively. Vaccine effectiveness was also robust at 74.6% in children with prior COVID-19 infection who received at least one vaccine dose.
Product Highlight - Mac Dual-Action
12 Sep 2023
Hexylresorcinol 2.4 mg lozenge
Product Highlight - ZAVICEFTA
12 Sep 2023
Ceftazidime 2 g, avibactam 0.5 g powder for concentrate for solution for infusion
Long COVID: What we have learned so far
Prof. Ghassan Dbaibo, 27 Apr 2023

The WHO defines long COVID as a condition that occurs 3 months from COVID-19 onset, whose symptoms last ≥2 months and cannot be attributed to an alternative diagnosis. In an interview with MIMS Doctor, Professor Ghassan Dbaibo of the Center for Infectious Diseases, American University of Beirut, Beirut, Lebanon, describes the evolving attitudes towards long COVID among healthcare professionals (HCPs), some unexpected predisposing factors, potential biological mechanisms behind prolonged symptom duration and shares data on vaccination’s protective effects against long COVID.

Optimizing executive function skills in children: What healthcare professionals should know
Dr. Evelyn Law, 04 Feb 2023
Executive function (EF) skills in childhood predict academic success better than a child’s intelligence quotient (IQ), and are associated with better physical health, more stable careers, and higher socioeconomic status in adulthood. [Psychol Sci 2005;16:939-944; J Clin Psychiatry 2012;73:941-950; Pediatrics 2013;131:637-644] Despite this, EF is an important topic that is often overlooked. To learn more about EF, MIMS Doctor interviewed Dr Evelyn Law, a clinician scientist specialising in developmental and behavioural paediatrics. Dr Law is Assistant Professor at the National University of Singapore Yong Loo Lin School of Medicine, Singapore.
Management of multidrug-resistant organisms in paediatric patients: Role of newer antimicrobial agents
Assoc Prof. Louis Grandjean, Adj Asst Prof. Natalie Tan, 01 Jul 2022

The management of multidrug-resistant (MDR) infections in children is complex, with limited studies and a relative lack of approved new antibiotics with paediatric indications.

At a recent Meet-the-Expert session, Dr Louis Grandjean, Consultant in Paediatric Infectious Diseases at Great Ormond Street Hospital and Associate Professor at University College, London, UK, addressed the growing threat of MDR infections in children and discussed treatment strategies and options for management. He focused on ceftazidime-avibactam (CAZ-AVI, Zavicefta®), whose approval in Singapore was recently expanded to include paediatric patients aged 3 months and older.

Adj Asst Prof Natalie Tan, Senior Consultant at KK Women’s and Children’s Hospital, Singapore, chaired this webinar, which was organized by Pfizer under the auspices of the Singapore Paediatric Society and KK Women’s and Children’s Hospital.

Bilastine in children – understanding principles and practice
24 Feb 2022
Allergic rhinitis is the most frequently occurring form of allergy in the world. It has a high burden in childhood, affecting sleep, concentration, and consecutively, learning. Professor Nikolaos Papadopoulos delivered a lecture on the evidence base and clinical experience supporting the use of Bilastine in children at the 11th Singapore Sleep, Allergy and Rhinology conference on 1 October 2020.
Conference Reports
Dupilumab reverses gene dysregulation in EoE
Jairia Dela Cruz, 24 Mar 2024
Treatment with dupilumab helps normalize the expression of genes dysregulated in children with active eosinophilic esophagitis (EoE), according to a study.
Dupilumab mends skin barrier in children with AD, but with caveat
Stephen Padilla, 19 Mar 2024
Use of dupilumab results in normalization of stratum corneum (SC) lipids, which is responsible for skin barrier function, in children with atopic dermatitis (AD) within 1 to 2 months of treatment, according to a study presented at AAAAI 2024.
Tapinarof cream effective regardless of AD severity, age in two trials
Elaine Soliven, 15 Mar 2024

Once-daily application of tapinarof cream 1% significantly improves the Eczema Area Severity Index (EASI) score in patients with atopic dermatitis (AD), regardless of their disease severity or age, according to the pivotal phase III ADORING 1 and 2 trials presented at AAAAI 2024.

TRuE-AD3: Ruxolitinib cream effective in children with AD
Elaine Soliven, 11 Mar 2024

Ruxolitinib cream, a topically administered selective Janus kinase 1/2 inhibitor, appears to be effective for mild-to-moderate atopic dermatitis (AD) in children aged 2–11 years, according to the TRuE-AD3 trial presented at AAAAI 2024.

Sebetralstat fares well as oral therapy for HAE
Audrey Abella, 08 Mar 2024
In the phase III KONFIDENT trial, oral sebetralstat provides rapid symptom relief, cuts treatment burden, and facilitates early treatment in individuals with hereditary angioedema (HAE) attacks.
OUtMATCH: Omalizumab gains FDA nod for IgE-mediated food allergies
Audrey Abella, 05 Mar 2024
Omalizumab scores in the NIH*-sponsored phase III OUtMATCH** trial, increasing the threshold for an allergic reaction to peanut and other common food allergens in children and adults with multiple food allergies.
Breastfeeding delivers long-term cardiometabolic benefits in offspring
Audrey Abella, 27 Feb 2024
In a secondary analysis of the HAPO FUS*, breastfeeding was found to be associated with lower rate of glucose metabolism disorders in the offspring; however, this association was not seen among the mothers.