Transthyretin Amyloidosis: An Expert’s View

Dr Jeremy Quah, Cardiology Fellow at National Heart Institute, talks about a rare disease known as transthyretin amyloidosis (ATTR).  

Amyloidosis is the extracellular tissue deposition of fibrils. There are two major forms of cardiac amyloidosis, namely light-chain amyloidosis (AL) and ATTR-CM. The clinical manifestations of ATTR-CM can vary greatly but essentially it presents as either new or worsening heart failure or new conduction system disease.