Abacavir Sulfate Atlanta Medicare

Abacavir Sulfate Atlanta Medicare



Viatris GmbH & Co


Atlanta Medicare
Concise Prescribing Info
Abacavir sulfate
Antiretroviral combination therapy for HIV infection in adults, adolescents & childn.
Dosage/Direction for Use
Adult, adolescent & childn (weighing at least 25 kg) 600 mg once daily. Alternatively, may be administered as 300 mg bid. Childn weighing ≥20 to <25 kg 150 mg in the morning & 300 mg in the evening or 450 mg once daily, 14 to <20 kg 150 mg bid or 300 mg once daily.
May be taken with or without food.
Special Precautions
End-stage renal disease. Mild or moderate hepatic impairment. High risk for hypersensitivity reactions in patients w/ HLA-B*5701 allele positive test result. Do not initiate therapy to patients who had been suspected of previous hypersensitivity on a abacavir-containing regimen. Do not re-initiate therapy after discontinuation of abacavir or abacavir-containing regimen. Do not re-initiate therapy after discontinuation of abacavir or abacavir-containing drugs' therapy. Lactic acidosis in association w/ hepatomegaly & hepatic steatosis. Patients w/ hepatomegaly, hepatitis or other known risk factors for liver disease & hepatic steatosis; infected w/ hepatitis C & treated w/ α interferon & ribavirin; discontinue in symptomatic setting of hyperlactatemia & metabolic/lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels. Mitochondrial dysfunction in HIV-negative infants exposed in utero & post-natally to nucleoside analogues. Lipodystrophy. Pancreatitis. Concomitant use w/ tenofovir disoproxil fumarate & lamivudine; ribavirin. Preexisting liver dysfunction including chronic active hepatitis; patients w/ significant underlying liver disorders. Chronic hepatitis B or C & treated w/ combination antiretroviral therapy. Immune reactivation syndrome. Osteonecrosis in patients w/ advanced HIV disease &/or long-term exposure to combination antiretroviral therapy. Opportunistic infections may still develop. MI. Pregnancy & lactation. Childn <3 mth.
Adverse Reactions
Anorexia; headache; nausea, vomiting, diarrhoea; rash (w/o systemic symptoms); fever, lethargy, fatigue.
Drug Interactions
Increase mean systemic clearance of methadone. Slightly decreased plasma conc w/ rifampicin, phenobarb & phenytoin. Reduce intracellular phosphorylation of ribavirin.
MIMS Class
ATC Classification
J05AF06 - abacavir ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Abacavir Sulfate Atlanta Medicare FC tab 300 mg
6 × 10's
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