Acemetacin helps relieve pain and inflammation associated with rheumatoid arthritis (inflammation in joints of fingers, wrist, feet, ankles) and osteoarthritis (damage of joints’ surfaces).
This medicine may also be used to treat low back pain and pain and inflammation after surgery.
Take Acemetacin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine together with food or immediately after a meal. Try to take it at the same time each day.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
Do not take Acemetacin if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to similar medicines such as ibuprofen, aspirin, or other NSAIDs (medicines for pain and inflammation).
Alert your doctor if you have the following conditions:
- stomach ulcer, bleeding or history of stomach ulcer, bleeding
- nasal polyps (noncancerous growths in the lining of the nose) caused by an allergic reaction
- history of bleeding in the stomach caused by taking NSAIDs
- blood disorders
- severe heart failure
- severe liver failure
- severe kidney failure
as Acemetacin may not be suitable for you.
Do not give Acemetacin to children unless instructed to do so by the doctor.
Inform your doctor if you have the following conditions:
- asthma or history of asthma
- history of high blood pressure and mild or moderate heart failure
- risk factors for heart disease (high levels of cholesterol in the blood, diabetes, smoking)
- history of inflammation of the bowel
- epilepsy (fits or seizures)
- mental illness
- Parkinson’s disease (a brain disease that affects movement)
- systemic lupus erythematosus or SLE (autoimmune disease that causes inflammation)
Let your doctor know if you are pregnant or breastfeeding.
Avoid exposure to anyone who is infected with chicken pox and herpes zoster virus. If you are exposed to these infections, contact your doctor immediately.
Be sure to check with your doctor or pharmacist before giving Acemetacin to an elderly person. Elderly people may be more sensitive to the side effects.
If you are going for an operation, inform your doctor or dentist that you are taking this medicine.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may need to perform tests to monitor your liver and kidney function while you are being treated with this medicine.
Acemetacin may cause drowsiness, dizziness, or visual disturbances. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.
Other side effects include any of the following: headache, ringing in the ears, nausea, vomiting, diarrhoea, indigestion, stomach wind, loss of appetite, tiredness, and hair loss.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- signs of allergic reaction e.g. swelling of the face, lips, tongue, throat, or mouth
- very bad stomach pain
- pass out blood or black, tarry stools or vomit coffee-ground-like vomitus
- unusual bleeding or bruising
- frequent and persistent sore throat with fever
- rashes with skin peeling or blisters / rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
- unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour)
- muscle weakness, cramping or numbness; fast or irregular heartbeat
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines for pain and inflammation e.g. aspirin, ibuprofen
- medicine for inflammation e.g. hydrocortisone, prednisone
- blood-thinning medicine e.g. warfarin
- medicine to treat depression e.g. escitalopram, lithium
- medicines for high blood pressure or heart disease e.g. amlodipine, digoxin
- diuretics or “water pils” e.g. furosemide, hydrochlorothiazide
- medicines for cancer e.g. methotrexate
- medicines used in organ transplant or certain immune disorders e.g. ciclosporin, tacrolimus
- certain antibiotic e.g. ciprofloxacin, amoxicillin
- medicines for HIV infection e.g. zidovudine
- medicine that reduce stomach acid production e.g. ranitidine
- medicine for gout e.g. probenecid
- medicine for mood disorders e.g. haloperidol
- medicine for epilepsy (fits) e.g. phenytoin
This list does not include all medicines that may interact with Acemetacin.
Acemetacin should not be taken with antacids as antacids could reduce the effectiveness of this medicine. If you must take antacid, there should be at least 2 hours interval between the antacid and Acemetacin.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.