Acular Description





Full Prescribing Info
Each mL of ophthalmic solution also contains benzalkonium chloride 0.01% as preservative and the following inactive ingredients: Disodium edetate 0.1%, octoxynol 40, sodium chloride, hydrochloric acid and/or sodium hydroxide to adjust the pH and purified water.
Acular has a pH of 7.4 and osmolality of 290 mOsmol/kg. It is a racemic mixture of R-(+) and S-(-) ketorolac tromethamine.
Ketorolac tromethamine, a member of the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs), is (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1). It has a molecular weight of 376.41. It may exist in 3 crystal forms. All forms are equally soluble in water. The pKa of ketorolac is 3.5. This white to off-white crystalline substance discolors on prolonged exposure to light.
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