Adant Dispo serves to cover and protect the surface of the articular cartilage, inhibits degenerative changes of the cartilage tissue, improves movability of the contracted joint, and inhibits articular pain.
Actions on the Articular Cartilage: Incorporation of Adant Dispo into the surface layer of cartilage was observed after injection into the intra-articular space of the knee of normal rabbits. The product distributed well in the cartilage tissue of patients with osteoarthritis of the knee (in vitro) from the surface layer to the deeper layers with the passage of time. This distribution corresponded to the sites where proteoglycans were lost.
Adant Dispo inhibited the release of proteoglycans from bovine articular cartilage cells (in vitro).
Adant Dispo inhibited further degeneration of the cartilage in the knee osteoarthritis model and fixed knee joint contracture model in rabbits by intra-articular injection.
Improvement of Articular Movability: Adant Dispo improved articular movability of the knee in a rabbit model of fixed knee joint contracture by intra-articular injection.
Pain Inhibitory Effect: Adant Dispo inhibited crystalline urate-induced pain of the knee joint in dogs.