Adenozin

Adenozin

adenosine

Manufacturer:

Swiss Parenterals

Distributor:

Cosma Medical

Marketer:

Cosma Medical
Concise Prescribing Info
Contents
Adenosine
Indications/Uses
Conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias (PSVT), including those associated w/ accessory by-pass tracts (Wolff-Parkinson-White Syndrome). Aid to diagnosis of broad or narrow complex supraventricular tachycardias. Sensitisation of intra-cavitary electrophysiological investigations.
Dosage/Direction for Use
Adult Initially 3 mg given as rapid IV bolus (over 2 sec) followed by 6 mg IV bolus as 2nd dose if 1st dose does not result in supraventricular tachycardia elimination w/in 1-2 min, or 12 mg IV bolus as 3rd dose if 2nd dose does not result in supraventricular tachycardia elimination w/in 1-2 min. Childn <50 kg Initially 0.05-0.1 mg/kg IV bolus given centrally or peripherally, followed by 2nd dose as additional bolus inj administer at incrementally higher doses by 0.05-0.1 mg/kg if PSVT conversion does not occur w/in 1-2 min, continue until sinus rhythm is established. Max dose: 0.3 mg/kg single dose (up to 12 mg).
Contraindications
Hypersensitivity. Sick sinus syndrome; 2nd or 3rd degree AV block (except in patients w/ a functioning artificial pacemaker); severe hypotension.
Special Precautions
Discontinue in patients who develop persistent or symptomatic hypotension, & severe resp difficulties. Patients w/ recent MI, severe heart failure, or minor conduction defects (1st degree AV block, bundle branch block); obstructive lung disease not associated w/ bronchoconstriction (eg, bronchitis, emphysema). Cardiac denervation in patients who have undergone cardiac transplantation. Avoid use in patients w/ bronchoconstriction or bronchospasm (eg, asthma). Possible transient cardiac arrhythmias. May develop increased conduction down the anomalous pathway in patients w/ atrial fibrillation or flutter & especially in those w/ an accessory by-pass tract. Continuous ECG monitoring during administration. Not recommended during pregnancy. Not to be used during lactation. Childn 0-18 yr.
Adverse Reactions
Facial flushing, chest pain, hypotension, palpitations; headache, light-headedness, dizziness, numbness, tingling in arms, apprehension; nausea, metallic taste, groin pressure, throat tightness; heaviness in arms, neck/back pain; dyspnea, hyperventilation; chest pressure, blurred vision, burning sensation, head pressure, sweating.
Drug Interactions
Inhibited cellular uptake & metabolism, & potentiated action w/ dipyridamole. Avoid use of theophylline & other xanthenes (methylxanthines) for 24 hr, & food & drinks containing xanthines (tea, coffee, chocolate & cola) for 12 hr prior to treatment. Drugs tend to impair cardiac conduction.
MIMS Class
Cardiac Drugs
ATC Classification
C01EB10 - adenosine ; Belongs to the class of other cardiac preparations.
Presentation/Packing
Form
Adenozin soln for inj 3 mg/mL
Packing/Price
2 mL x 10 × 1's;2 mL x 1's
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