The most frequently reported adverse reactions include ulcerative stomatitis, leukopenia nausea and abdominal distress. Other frequently reported adverse effects are malaise, undue fatigue, chills and fever, dizziness and decreased resistance to infection.
Other adverse reactions include: Alimentary system:
Gingivitis, pharyngitis, stomatitis, anorexia, nausea, vomiting, diarrhoea, hematemesis, melena, gastrointestinal ulceration and bleeding enteritis.
Headache, drowsiness, blurred vision, aphasia hemiparesis, paresis, convulsions have been reported.
Erythematous rashes, pruritis, urticaria photosensitivity, pigmentary changes, alopecia, ecchymosis, telangiectasia, acne, furunculosis.
Renal failure, azotemia, cystitis, hematuria, menstrual dysfunction, infertility, abortion, fetal defects.
Bone marrow depression, leucopenia, thrombocytopenia, anaemia and septicaemia.
Pneumonitis, arthralgia, myalgia, impotence, diabetes, osteoporosis, sudden death and anaphylaxis.