Aloxi

Aloxi Description

palonosetron

Manufacturer:

Mundipharma

Distributor:

DKSH
Full Prescribing Info
Description
ALOXI (palonosetron hydrochloride) is an antiemetic and antinauseant agent. It is serotonin-3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical formula is C19H24N2O·HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer.
Palonosetron hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.
ALOXI injection is a sterile, clear, colorless, non pyrogenic, isotonic, buffered solution for intravenous administration. ALOXI injection is available as 5 mL single use vial. Each 5 mL contains 0.25 mg palonosetron base as 0.28 mg palonosetron hydrochloride, 207.5 mg mannitol, disodium edetate and citrate buffer in water for intravenous administration.
The pH of the solution in the 5 mL vial is 4.5 to 5.5.
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